Document Detail


Control of Pseudomonas aeruginosa skin infections in mice is mast cell-dependent.
MedLine Citation:
PMID:  17525259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mast cells (MCs) have recently been shown to be essential for the elicitation of efficient immune responses in murine sepsis. To explore whether MCs also contribute to the control of bacterial skin infections, we studied skin lesions induced by Pseudomonas aeruginosa (PA) in genetically MC-deficient Kit(W)/Kit(W-v) mice, normal Kit(+/+) mice, and MC-reconstituted Kit(W)/Kit(W-v) mice. PA injections resulted in strikingly (>2-fold) larger skin lesions in Kit(W)/Kit(W-v) mice than in Kit(+/+) mice, which exhibited pronounced MC degranulation at infection sites. In addition, neutrophil recruitment following PA injections and bacterial clearance from sites of infection was significantly impaired in Kit(W)/Kit(W-v) mice compared with Kit(+/+) mice. Notably, the adoptive transfer of MCs to the skin of Kit(W)/Kit(W-v) mice before PA infection resulted in normal neutrophil accumulation as well as skin lesions comparable with those in Kit(+/+) mice in both bacterial burden and size. These findings demonstrate for the first time that activated MCs are crucial for the induction of protective innate immune responses to bacterial skin infections.
Authors:
Frank Siebenhaar; Wolfgang Syska; Karsten Weller; Markus Magerl; Torsten Zuberbier; Martin Metz; Marcus Maurer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  170     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-25     Completed Date:  2007-07-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1910-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Mast Cells / immunology*
Mice
Mice, Inbred C57BL
Mice, Knockout
Neutrophils / metabolism
Proto-Oncogene Proteins c-kit / genetics,  metabolism
Pseudomonas Infections / immunology*,  pathology
Pseudomonas aeruginosa
Skin* / cytology,  immunology,  microbiology,  pathology
Skin Diseases, Infectious* / immunology,  microbiology,  pathology
Chemical
Reg. No./Substance:
EC 2.7.10.1/Proto-Oncogene Proteins c-kit
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