Document Detail


The Control of Male Sexual Responses.
MedLine Citation:
PMID:  23360268     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Male sexual responses are reflexes mediated by the spinal cord and modulated by neural circuitries involving both the peripheral and central nervous system. While the brain interact with the reflexes to allow perception of sexual sensations and to exert excitatory or inhibitory influences, penile reflexes can occur despite complete transections of the spinal cord, as demonstrated by the reviewed animal studies on spinalization and human studies on spinal cord injury. Neurophysiological and neuropharmacological substrates of the male sexual responses will be discussed in this review, starting with the spinal mediation of erection and its underlying mechanism with nitric oxide (NO), followed by the description of the ejaculation process, its neural mediation and its coordination by the spinal generator of ejaculation (SGE), followed by the occurrence of climax as a multisegmental sympathetic reflex discharge. Brain modulation of these reflexes will be discussed through neurophysiological evidence involving structures such as the medial preoptic area of hypothalamus (MPOA), the paraventricular nucleus (PVN), the periaqueductal gray (PAG), and the nucleus para-gigantocellularis (nPGI), and through neuropharmacological evidence involving neurotransmitters such as serotonin (5-HT), dopamine and oxytocin. The pharmacological developments based on these mechanisms to treat male sexual dysfunctions will complete this review, including phosphodiesterase (PDE-5) inhibitors and intracavernous injections (ICI) for the treatment of erectile dysfunctions (ED), selective serotonin reuptake inhibitor (SSRI) for the treatment of premature ejaculation, and cholinesterase inhibitors as well as alpha adrenergic drugs for the treatment of anejaculation and retrograde ejaculation. Evidence from spinal cord injured studies will be highlighted upon each step.
Authors:
Frédérique Courtois; Serge Carrier; Kathleen Charvier; Pierre A Guertin; Nicolas Morel Journel
Related Documents :
17251428 - The induction levels of heat shock protein 70 differentiate the vulnerabilities to muta...
24259078 - Heliothis virescens: response characteristics of receptor neurons in sensilla trichodea...
20352108 - Induction of autophagy by cystatin c: a mechanism that protects murine primary cortical...
20510858 - Retrograde bmp signaling controls synaptic growth at the nmj by regulating trio express...
12424268 - Rhythmic properties of neurons in the rostral ventrolateral medulla of the rat in vitro...
9760078 - Efferent projection from the rostral ventrolateral medulla to the area postrema in rats.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Current pharmaceutical design     Volume:  -     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Université du Québec à Montréal Département de Sexologie CP 8888, Succursale Centre-Ville Montréal, Québec H3C 3P8, Canada. courtois.frederique@uqam.ca.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of descending aminergic pathways in the development of locomotion.
Next Document:  Control and Role of Plateau Potential Properties in the Spinal Cord.