| Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. | |
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MedLine Citation:
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PMID: 7859287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The phyllopod (phyl) gene regulates the fates of a subset of cells in the developing Drosophila eye; in the absence of phyl function, the R1, R6, and R7 photoreceptors are transformed into additional cone cells, whereas ectopic phyl expression in the cone cell precursors transforms these cells into additional R7 cells. Within this group of cells, phyl expression thus mimics activation of the Raf pathway in its ability to induce photoreceptor rather than cone cell development. Furthermore, the transformation of cone cells into R7 cells in response to Raf activation is both accompanied by and dependent upon ectopic phyl expression. phyl thus represents a possible target gene of the Raf pathway during eye development, controlling the fates of a novel subset of photoreceptors. |
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Authors:
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B J Dickson; M Domínguez; A van der Straten; E Hafen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 80 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-03-20 Completed Date: 1995-03-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 453-62 Citation Subset: IM |
Affiliation:
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Zoologisches Institut, Universität Zürich, Switzerland. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/L38294 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cell Differentiation Cloning, Molecular Crosses, Genetic Drosophila / enzymology, genetics* Drosophila Proteins* Eye / chemistry, growth & development Gene Dosage Gene Expression Regulation, Developmental* Genes, Insect / genetics Larva Molecular Sequence Data Nuclear Proteins / genetics*, physiology Photoreceptor Cells, Invertebrate / cytology*, growth & development Protein-Serine-Threonine Kinases / genetics, physiology* Proto-Oncogene Proteins / genetics, physiology* Proto-Oncogene Proteins c-raf RNA, Messenger / analysis Sequence Analysis, DNA Suppression, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; 0/RNA, Messenger; 0/phyllopod protein, Drosophila; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-raf |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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