Document Detail

Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase.
MedLine Citation:
PMID:  7859287     Owner:  NLM     Status:  MEDLINE    
The phyllopod (phyl) gene regulates the fates of a subset of cells in the developing Drosophila eye; in the absence of phyl function, the R1, R6, and R7 photoreceptors are transformed into additional cone cells, whereas ectopic phyl expression in the cone cell precursors transforms these cells into additional R7 cells. Within this group of cells, phyl expression thus mimics activation of the Raf pathway in its ability to induce photoreceptor rather than cone cell development. Furthermore, the transformation of cone cells into R7 cells in response to Raf activation is both accompanied by and dependent upon ectopic phyl expression. phyl thus represents a possible target gene of the Raf pathway during eye development, controlling the fates of a novel subset of photoreceptors.
B J Dickson; M Domínguez; A van der Straten; E Hafen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  80     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-20     Completed Date:  1995-03-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  453-62     Citation Subset:  IM    
Zoologisches Institut, Universität Zürich, Switzerland.
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MeSH Terms
Amino Acid Sequence
Cell Differentiation
Cloning, Molecular
Crosses, Genetic
Drosophila / enzymology,  genetics*
Drosophila Proteins*
Eye / chemistry,  growth & development
Gene Dosage
Gene Expression Regulation, Developmental*
Genes, Insect / genetics
Molecular Sequence Data
Nuclear Proteins / genetics*,  physiology
Photoreceptor Cells, Invertebrate / cytology*,  growth & development
Protein-Serine-Threonine Kinases / genetics,  physiology*
Proto-Oncogene Proteins / genetics,  physiology*
Proto-Oncogene Proteins c-raf
RNA, Messenger / analysis
Sequence Analysis, DNA
Suppression, Genetic
Reg. No./Substance:
0/Drosophila Proteins; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; 0/RNA, Messenger; 0/phyllopod protein, Drosophila; EC Kinases; EC Proteins c-raf

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