| Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1. | |
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MedLine Citation:
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PMID: 19948791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Entry into mitosis is universally controlled by cyclin-dependent kinases (CDKs). A key regulatory event in metazoans and fission yeast is CDK activation by the removal of inhibitory phosphate groups in the ATP binding pocket catalyzed by Cdc25 phosphatases. In contrast with other multicellular organisms, we show here that in the flowering plant Arabidopsis thaliana, cell cycle control does not depend on sudden changes in the phosphorylation pattern of the PSTAIRE-containing Cdk1 homolog CDKA;1. Consistently, we found that neither mutants in a previously identified CDC25 candidate gene nor plants in which it is overexpressed display cell cycle defects. Inhibitory phosphorylation of CDKs is also the key event in metazoans to arrest cell cycle progression upon DNA damage. However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1. These observations reveal a surprising degree of divergence in the circuitry of highly conserved core cell cycle regulators in multicellular organisms. Based on biomathematical simulations, we propose a plant-specific model of how progression through the cell cycle could be wired in Arabidopsis. |
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Authors:
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Nico Dissmeyer; Annika K Weimer; Stefan Pusch; Kristof De Schutter; Claire Lessa Alvim Kamei; Moritz K Nowack; Bela Novak; Gui-Lan Duan; Yong-Guan Zhu; Lieven De Veylder; Arp Schnittger |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-30 |
Journal Detail:
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Title: The Plant cell Volume: 21 ISSN: 1532-298X ISO Abbreviation: Plant Cell Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2010-01-01 Completed Date: 2010-03-22 Revised Date: 2011-09-08 |
Medline Journal Info:
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Nlm Unique ID: 9208688 Medline TA: Plant Cell Country: United States |
Other Details:
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Languages: eng Pagination: 3641-54 Citation Subset: IM |
Affiliation:
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Unigruppe am Max-Planck-Institut für Züchtungsforschung, Max-Delbrück-Laboratorium, Lehrstuhl für Botanik III, Universität zu Köln, Köln, Germany. diss@mpiz-koeln.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arabidopsis
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genetics*,
growth & development,
metabolism Arabidopsis Proteins / genetics*, metabolism Binding Sites / genetics CDC2 Protein Kinase / genetics, metabolism Cell Cycle / genetics Cell Cycle Proteins / genetics*, metabolism Cell Proliferation* Cyclin-Dependent Kinases / genetics*, metabolism DNA Damage / genetics* DNA Repair / genetics* Evolution, Molecular Genes, cdc / physiology Mathematics Mitosis / genetics Phosphorylation Plant Structures / genetics, growth & development, metabolism cdc25 Phosphatases / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Arabidopsis Proteins; 0/CDKA1 protein, Arabidopsis; 0/Cell Cycle Proteins; EC 2.7.11.22/CDC2 Protein Kinase; EC 2.7.11.22/Cyclin-Dependent Kinases; EC 3.1.3.48/cdc25 Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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