| Contributory role of matrix metalloproteinases in cardiovascular remodeling. | |
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MedLine Citation:
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PMID: 12769658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in cardiovascular tissue structure can result in alterations in function. This process occurs as a continuum and can be defined as cardiovascular remodeling. A family of zinc dependent proteases known as the matrix metalloproteinases (MMPs) has been demonstrated to cause tissue remodeling. A number of past studies have demonstrated increased expression and activation of MMPs in both myocardial and vascular remodeling processes. Experimental results support the concept that the MMPs directly contribute to progressive myocardial remodeling post-myocardial infarction and in cardiomyopathic disease. Within the vascular compartment, compelling evidence exists for the contributory role of MMPs in atheromatous plaque rupture and aortic aneurysms. Therefore, the purpose of this review is to examine recent studies of this proteolytic system in the context of cardiovascular remodeling. |
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Authors:
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S K Gunasinghe; J Ikonomidis; F G Spinale |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current drug targets. Cardiovascular & haematological disorders Volume: 1 ISSN: 1568-0061 ISO Abbreviation: Curr Drug Targets Cardiovasc Haematol Disord Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2003-05-28 Completed Date: 2003-06-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 101123341 Medline TA: Curr Drug Targets Cardiovasc Haematol Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 75-91 Citation Subset: IM |
Affiliation:
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Cardiothoracic Surgery, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / enzymology* Gene Expression Regulation, Enzymologic / physiology Humans Matrix Metalloproteinases / metabolism* Ventricular Remodeling / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL 45024/HL/NHLBI NIH HHS; HL 97012/HL/NHLBI NIH HHS; P01 HL 48788/HL/NHLBI NIH HHS; T32 HL 07260-25/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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