Document Detail


Contributory role of matrix metalloproteinases in cardiovascular remodeling.
MedLine Citation:
PMID:  12769658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in cardiovascular tissue structure can result in alterations in function. This process occurs as a continuum and can be defined as cardiovascular remodeling. A family of zinc dependent proteases known as the matrix metalloproteinases (MMPs) has been demonstrated to cause tissue remodeling. A number of past studies have demonstrated increased expression and activation of MMPs in both myocardial and vascular remodeling processes. Experimental results support the concept that the MMPs directly contribute to progressive myocardial remodeling post-myocardial infarction and in cardiomyopathic disease. Within the vascular compartment, compelling evidence exists for the contributory role of MMPs in atheromatous plaque rupture and aortic aneurysms. Therefore, the purpose of this review is to examine recent studies of this proteolytic system in the context of cardiovascular remodeling.
Authors:
S K Gunasinghe; J Ikonomidis; F G Spinale
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current drug targets. Cardiovascular & haematological disorders     Volume:  1     ISSN:  1568-0061     ISO Abbreviation:  Curr Drug Targets Cardiovasc Haematol Disord     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101123341     Medline TA:  Curr Drug Targets Cardiovasc Haematol Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  75-91     Citation Subset:  IM    
Affiliation:
Cardiothoracic Surgery, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Diseases / enzymology*
Gene Expression Regulation, Enzymologic / physiology
Humans
Matrix Metalloproteinases / metabolism*
Ventricular Remodeling / physiology*
Grant Support
ID/Acronym/Agency:
HL 45024/HL/NHLBI NIH HHS; HL 97012/HL/NHLBI NIH HHS; P01 HL 48788/HL/NHLBI NIH HHS; T32 HL 07260-25/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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