Document Detail


Contributions of the middle ear to the development of function in the cochlea.
MedLine Citation:
PMID:  3198506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The contribution of middle ear immaturities to the development of cochlear microphonic potential (CM) responses was studied throughout the ontogeny of auditory function in the Mongolian gerbil. CM produced by direct mechanical stimulation of the stapes was compared with CM generated by acoustic stimulation of the intact ear at various postnatal ages. The results indicated that during development acoustically generated CM reflects middle ear as well as inner ear maturational factors. With direct stapes driving, CM was first elicited at 10 days after birth (DAB), two days earlier than with acoustic stimulation. Controlling for the contributions of middle ear immaturity, maturation of the inner ear accounted for approximately a 75 dB improvement in CM thresholds between 10 and 18 DAB. Comparisons between the results obtained with the acoustic and stapes driving stimulation protocols suggested that the major maturational changes in the middle ear conduction apparatus occurred between 14 and 16 DAB. This period was associated with the final stages of resorption of middle ear mesenchyme and ossicular ossification. Before 16 DAB, acoustically evoked CM thresholds reflect approximately a 25 dB loss in sensitivity due to middle ear immaturity.
Authors:
N K Woolf; A F Ryan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  35     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-01-18     Completed Date:  1989-01-18     Revised Date:  2013-01-25    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  131-42     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of California, San Diego Medical School, La Jolla 92093.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Age Factors
Animals
Cochlea / physiology
Cochlear Microphonic Potentials*
Ear, Middle / growth & development*
Evoked Potentials, Auditory*
Gerbillinae
Stapes / physiology
Grant Support
ID/Acronym/Agency:
I01 BX001205/BX/BLRD VA; NS14945/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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