Document Detail


Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast.
MedLine Citation:
PMID:  22840513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A paradigm of cytokinesis in animal cells is that the actomyosin contractile ring provides the primary force to divide the cell. In the fission yeast Schizosaccharomyces pombe, cytokinesis also involves a conserved cytokinetic ring, which has been generally assumed to provide the force for cleavage (see also [5]). However, in contrast to animal cells, cytokinesis in yeast cells also requires the assembly of a cell wall septum, which grows centripetally inward as the ring closes. Fission yeast, like other walled cells, also possess high (MPa) turgor pressure. Here, we show that turgor pressure is an important factor in the mechanics of cytokinesis. Decreasing effective turgor pressure leads to an increase in cleavage rate, suggesting that the inward force generated by the division apparatus opposes turgor pressure. The contractile ring, which is predicted to provide only a tiny fraction of the mechanical stress required to overcome turgor, is largely dispensable for ingression; once septation has started, cleavage can continue in the absence of the contractile ring. Scaling arguments and modeling suggest that the large forces for cytokinesis are not produced by the contractile ring but are driven by the assembly of cell wall polymers in the growing septum.
Authors:
Stephen A Proctor; Nicolas Minc; Arezki Boudaoud; Fred Chang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-26
Journal Detail:
Title:  Current biology : CB     Volume:  22     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-02-21     Revised Date:  2013-09-16    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1601-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Microbiology & Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Actomyosin / metabolism,  physiology
Cell Wall / metabolism
Cytokinesis / physiology*
Pressure
Schizosaccharomyces / cytology*,  metabolism
Grant Support
ID/Acronym/Agency:
GM056836/GM/NIGMS NIH HHS; R01 GM056836/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9013-26-7/Actomyosin
Comments/Corrections

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