Document Detail


Contributions of electron microscopy to understand secretion of immune mediators by human eosinophils.
MedLine Citation:
PMID:  20875166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. In response to varied stimuli, eosinophils are recruited from the circulation into inflammatory foci, where they modulate immune responses through the release of granule-derived products. Transmission electron microscopy (TEM) is the only technique that can clearly identify and distinguish between different modes of cell secretion. In this review, we highlight the advances in understanding mechanisms of eosinophil secretion, based on TEM findings, that have been made over the past years and that have provided unprecedented insights into the functional capabilities of these cells.
Authors:
Rossana C N Melo; Ann M Dvorak; Peter F Weller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-09-27
Journal Detail:
Title:  Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada     Volume:  16     ISSN:  1435-8115     ISO Abbreviation:  Microsc. Microanal.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-11     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9712707     Medline TA:  Microsc Microanal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cytokines / secretion*
Eosinophils / metabolism*,  ultrastructure*
Humans
Inflammation Mediators / metabolism*
Microscopy, Electron / methods*
Grant Support
ID/Acronym/Agency:
AI020241/AI/NIAID NIH HHS; AI022571/AI/NIAID NIH HHS; AI051645/AI/NIAID NIH HHS; R01 AI022571/AI/NIAID NIH HHS; R01 AI051645/AI/NIAID NIH HHS; R01 AI051645-09/AI/NIAID NIH HHS; R37 AI020241-27/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators
Comments/Corrections

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