Document Detail


Contributions of ERK signaling in the striatum to instrumental learning and performance.
MedLine Citation:
PMID:  21147168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The striatum is critical for learning and decision making; however, the molecular mechanisms that govern striatum function are not fully understood. The extracellular signal regulated kinase (ERK) cascade is an important signaling pathway that underlies synaptic plasticity, cellular excitability, learning and arousal. This review focuses on the role of ERK signaling in striatum function. ERK is activated in the striatum by coordinated dopamine and glutamate receptor signaling, where it underlies corticostriatal synaptic plasticity and influences striatal cell excitability. ERK activation in the dorsal striatum is necessary for action-outcome learning and performance of goal-directed actions. In the ventral striatum, ERK is necessary for the motivating effects of reward-associated stimuli on instrumental performance. Dysregulation of ERK signaling in the striatum by repeated drug exposure contributes to the development of addictive behavior. These results highlight the importance of ERK signaling in the striatum as a critical substrate for learning and as a regulator of ongoing behavior. Furthermore, they suggest that ERK may be a suitable target for therapeutics to treat disorders of learning and decision making that arise from compromised striatum function.
Authors:
Michael W Shiflett; Bernard W Balleine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-12-13
Journal Detail:
Title:  Behavioural brain research     Volume:  218     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-17     Completed Date:  2011-05-25     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  240-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / physiology*
Corpus Striatum / physiology*
Extracellular Signal-Regulated MAP Kinases / metabolism*
Neuronal Plasticity / physiology
Neurons / physiology
Signal Transduction / physiology*
Grant Support
ID/Acronym/Agency:
DA026559/DA/NIDA NIH HHS; HD059527/HD/NICHD NIH HHS; R01 HD059257/HD/NICHD NIH HHS; R01 HD059257-02/HD/NICHD NIH HHS; R01 MH056446/MH/NIMH NIH HHS; R03 DA026559-01/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases
Comments/Corrections

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