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The contributions of antioxidant activity of lipoic Acid in reducing neurogenerative progression of Parkinson's disease: a review.
MedLine Citation:
PMID:  21126109     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT This work reviews the evidence of the mechanism of neuronal degeneration in Parkinson's disease (PD) and the neuroprotective effect of lipoic acid and its use in the treatment of PD. PD is characterized by slow and progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta, leading to reduction of the striatal dopaminergic terminals. It is known that several factors influence neuronal damage. Among these factors, oxidative stress, immune system activity, microglial cells, and apoptotic mechanisms are of major importance. Currently, several antioxidants have been studied with the aim of reducing/slowing the progression of neurodegenerative processes. Lipoic acid is considered a universal antioxidant because it is an amphipathic substance. Lipoic acid and its reduced form, dihidrolipoic acid, act against reactive oxygen species, reducing oxidative stress. Therefore, this antioxidant has been used in the treatment of many diseases, including a new perspective for the treatment of Parkinson's disease.
Authors:
Dayane Pessoa De Araújo; Rodrigo De Freitas Guimarães Lobato; José Rodolfo Lopes De Paiva Cavalcanti; Luis Rafael Leite Sampaio; Paulo Victor Pontes Araújo; Marcia Calheiros Chaves Silva; Kelly Rose Tavares Neves; Marta Maria De França Fonteles; Francisca Clea Florenço De Sousa; Silvania Maria Mendes Vasconcelos
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Publication Detail:
Type:  Journal Article     Date:  2010-12-02
Journal Detail:
Title:  The International journal of neuroscience     Volume:  121     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Affiliation:
1Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Brazil.
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