Document Detail


Contribution of yeast models to neurodegeneration research.
MedLine Citation:
PMID:  22910375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As a model organism Saccharomyces cerevisiae has greatly contributed to our understanding of many fundamental aspects of cellular biology in higher eukaryotes. More recently, engineered yeast models developed to study endogenous or heterologous proteins that lay at the root of a given disease have become powerful tools for unraveling the molecular basis of complex human diseases like neurodegeneration. Additionally, with the possibility of performing target-directed large-scale screenings, yeast models have emerged as promising first-line approaches in the discovery process of novel therapeutic opportunities against these pathologies. In this paper, several yeast models that have contributed to the uncovering of the etiology and pathogenesis of several neurodegenerative diseases are described, including the most common forms of neurodegeneration worldwide, Alzheimer's, Parkinson's, and Huntington's diseases. Moreover, the potential input of these cell systems in the development of more effective therapies in neurodegeneration, through the identification of genetic and chemical suppressors, is also addressed.
Authors:
Clara Pereira; Cláudia Bessa; Joana Soares; Mariana Leão; Lucília Saraiva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-15
Journal Detail:
Title:  Journal of biomedicine & biotechnology     Volume:  2012     ISSN:  1110-7251     ISO Abbreviation:  J. Biomed. Biotechnol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-22     Completed Date:  2012-11-23     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101135740     Medline TA:  J Biomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  941232     Citation Subset:  IM    
Affiliation:
REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto, Portugal. clarafrancisco@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomedical Research*
Humans
Models, Biological*
Nerve Tissue Proteins / metabolism
Neurodegenerative Diseases / metabolism,  pathology*
Yeasts / metabolism*
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins
Comments/Corrections

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