| Contribution of voltage-gated sodium channels to b- and d-waves of frog electroretinogram under different conditions of light adaptation. | |
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MedLine Citation:
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PMID: 19854212 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The effect of blockade of voltage-gated sodium (Na(v)) channels by tetrodotoxin (TTX) on the V-log I function of the ERG b- and d-waves was investigated in light and dark adapted frog eyecups. TTX diminished the b- and d-wave amplitude under both conditions of adaptation at all stimulus intensities except for the middle intensity range in dark adapted eyes, where it had no effect on the b-wave amplitude. TTX delayed the time course of the responses, obtained with low intensity stimuli and widened the dynamic range of the b-wave. The inhibitory effect of TTX on the cone-mediated, but not rod-mediated b- and d-wave amplitude persisted after the blockade of proximal retinal activity by NMDA, indicating that it may be due to a blockade of Na(v) channels on the ON and OFF bipolar cells. |
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Authors:
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E Popova; P Kupenova |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vision research Volume: 50 ISSN: 1878-5646 ISO Abbreviation: Vision Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417402 Medline TA: Vision Res Country: England |
Other Details:
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Languages: eng Pagination: 88-98 Citation Subset: IM |
Affiliation:
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Department of Physiology, Medical Faculty, Medical University, 1431 Sofia, Bulgaria. epopova@abv.bg |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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