Document Detail

Contribution of vagal afferents to the volume-timing response to expiratory loads in neonatal lambs.
MedLine Citation:
PMID:  8728471     Owner:  NLM     Status:  MEDLINE    
Expiratory loads elicit volume-dependent reflex increases in expiratory duration (TE) in adult animals. This reflex is mediated by pulmonary vagal afferents. It was hypothesized that this same reflex in newborn lambs is mediated by vagal afferents. Single-breath graded expiratory loads were presented to 4 day old, anesthetized neonatal lambs through a facemask (FM), via tracheostomy (TR) and after the cervical vagi were severed bilaterally in the TR animals (VAG). In FM and TR studies, expired volume (VE) decreased and TE increased with increasing load magnitude. There was no significant difference in the VE-TE curves for FM and TR. These results demonstrate that pulmonary vagal afferents are mediating the volume-related reflex modulation of TE during expiratory loading in the anesthetized neonatal lamb which is unaffected by bypass (TR) of upper airway afferents.
B Webb; A A Hutchison; P W Davenport
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  207     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM; S    
Department of Physiological Sciences, University of Florida, Gainesville 32610, USA.
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MeSH Terms
Pulmonary Ventilation / physiology
Reflex / physiology*
Respiration / physiology*
Vagus Nerve / physiology*
Grant Support

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