Document Detail

Contribution to the genetics of symptomatic generalized tonic-clonic seizures: waking and sleep EEGs in siblings.
MedLine Citation:
PMID:  8825265     Owner:  NLM     Status:  MEDLINE    
The presence of epileptiform activity (EA) in the EEG of patients' relatives points to the significance of genetics in the etiology of epilepsies. Waking and sleep EEGs were recorded in 83 siblings of 54 patients suffering from symptomatic generalized tonic-clonic seizures. EA was recorded in at least one sibling of 27 (50%) of the 54 patients. When the 83 siblings are taken as a basis, EA was found in 34 (41%) of them. Generalized spike-wave discharges were seen in 32 cases; 2 siblings showed benign sharp wave foci in the right parietal area. EA was seen only in sleep in 44.1%. The highest rates of EA were seen in the age range up to 15 years. EA was found in 15 of 50 male siblings (30%), but in 18 of 33 female siblings (54.5%). Therefore genetics also play an import role in the etiology of symptomatic generalized tonic-clonic seizures.
R Degen; H E Degen; K Ahlemeyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  93     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-11-12     Completed Date:  1996-11-12     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
Epilepsy Centre Bethel, Bielefeld, Germany.
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MeSH Terms
Cerebral Cortex / physiopathology
Child, Preschool
Epilepsy, Tonic-Clonic / genetics*,  physiopathology
Evoked Potentials / genetics,  physiology
Sleep Stages / genetics*,  physiology
Wakefulness / genetics*,  physiology

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