Document Detail

Contribution of serotonin to liver injury following canine small-intestinal ischemia and reperfusion.
MedLine Citation:
PMID:  11421599     Owner:  NLM     Status:  MEDLINE    
Intestinal ischemia and reperfusion (I/R) has been shown to be associated with multiple organ damages. Serotonin (5-hydroxytriptamine; 5-HT), which is synthesized in the enterochromaffin cells in the intestine and stored in platelets, is known to play an important role in platelet aggregation and vasoconstriction and may ultimately enhance such organ injuries. The purpose of this study was to investigate the association between liver damage and 5-HT levels in the liver after intestinal I/R. The entire canine small intestine, isolated on a vascular pedicle that consisted of the proximal superior mesenteric artery and superior mesenteric vein, was subjected to 4-h ischemia by clamping these vessels and the marginal arteries supplying the proximal and distal ends of the small intestine. Hepatic blood flow, liver tissue blood flow, bile flow rate, and hepatic venous ketone body ratio (HVKBR) were measured before and at the end of intestinal ischemia and at 5, 15, and 30 min, and 1 and 2 h after reperfusion. 5-HT levels in plasma of the portal vein and hepatic vein were assayed at the same intervals. Time-matched, sham-operated animals served as controls. Intestinal I/R significantly decreased the liver tissue flow, bile flow rate, and HVKBR. Compared to those in controls, 5-HT levels in the portal vein and hepatic vein were markedly increased after reperfusion. Furthermore, intravenous administration of 5-HT receptor antagonists attenuated the liver dysfunction after intestinal reperfusion. These results suggest that intestinal I/R induces continuous disturbance of hepatic microcirculation, leading to liver dysfunction, and that 5-HT may be implicated as one of the mediators of liver dysfunction after intestinal I/R.
N Nakamura; N Hamada; R Murata; A Kobayashi; N Ishizaki; A Taira; R Sakata
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  99     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-25     Completed Date:  2001-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Second Department of Surgery, Faculty of Medicine, Kagoshima University, Kagoshima, 890-8520, Japan.
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MeSH Terms
Hepatic Artery / physiopathology
Hepatic Veins
Intestine, Small / blood supply*
Ischemia / pathology*,  physiopathology
Ketone Bodies / blood
Liver / pathology*
Portal Vein / physiopathology
Regional Blood Flow
Reperfusion Injury / pathology*,  physiopathology
Serotonin / blood,  physiology*
Reg. No./Substance:
0/Ketone Bodies; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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