| Contribution of nitric oxide to cerebral blood flow regulation under hypoxia in rats. | |
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MedLine Citation:
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PMID: 20927617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to clarify whether nitric oxide (NO) participates in the regulation of local cerebral blood flow (CBF) during hypoxia (inhalation of 15% O(2) in N(2)). The CBF response to hind-paw stimulation (evoked CBF) of Sprague-Dawley (SD) rats was measured by laser-Doppler flowmetry. Physiological variables, such as heart rate, mean blood pressure, and PaCO(2) during hypoxia, were identical to those under normoxic conditions. Hypoxia increased the baseline CBF (17.5 ± 14.3%) and the normalized peak amplitude of evoked CBF (31.1 ± 18.5%) relative to those during normoxia. When an NOS inhibitor was infused intravenously, these differences were abolished in both the baseline CBF or evoked CBF between normoxic and hypoxic conditions, whereas the heart rate decreased and the mean blood pressure increased during hypoxia in comparison with these during normoxia. The field potential was constant under all experimental conditions. These results suggest that NO plays a major role in the regulation of baseline and evoked CBF during hypoxia. |
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Authors:
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Hiroyuki Takuwa; Tetsuya Matsuura; Rumiana Bakalova; Takayuki Obata; Iwao Kanno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-07 |
Journal Detail:
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Title: The journal of physiological sciences : JPS Volume: 60 ISSN: 1880-6562 ISO Abbreviation: J Physiol Sci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 399-406 Citation Subset: IM |
Affiliation:
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Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan. takuwa@nirs.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / physiopathology* Cerebrovascular Circulation / drug effects* Laser-Doppler Flowmetry Nitric Oxide / physiology* Nitric Oxide Synthase / antagonists & inhibitors Nitroarginine / pharmacology Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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