Document Detail

Contribution of methylated exudate flavonoids to the anti-inflammatory activity of Grindelia robusta.
MedLine Citation:
PMID:  19278665     Owner:  NLM     Status:  MEDLINE    
The flavonoid pattern of an acetonic extract of Grindelia robusta Nutt. was investigated in detail. The flavonoids were enriched by CC. In addition to twelve known methylated exudate flavonols four compounds were identified for the first time in G. robusta. Several substances of the flavonoid complex, among them the main compounds quercetin-3-methylether and 6-OH-kaempferol-3,6-dimethylether, were tested for their activity to inhibit neutrophil elastase. Quercetin-3-methylether was shown to be most active with an IC(50) of 19 microM, thus obviously contributing to the anti-inflammatory activity of the drug.
Liselotte Krenn; Eckhard Wollenweber; Katja Steyrleuthner; Cornelia Görick; Matthias F Melzig
Publication Detail:
Type:  Journal Article     Date:  2009-03-09
Journal Detail:
Title:  Fitoterapia     Volume:  80     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  267-9     Citation Subset:  IM    
Department of Pharmacognosy, University of Vienna, PharmaCenter Vienna, Vienna, Austria.
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MeSH Terms
Anti-Inflammatory Agents / isolation & purification*,  pharmacology
Flavonoids / isolation & purification*,  pharmacology
Flavonols / isolation & purification*,  pharmacology
Grindelia / chemistry*
Leukocyte Elastase / antagonists & inhibitors*
Plant Extracts / chemistry,  isolation & purification*,  pharmacology
Plants, Medicinal / chemistry
Reg. No./Substance:
0/6-OH-kaempferol-3,6-dimethylether; 0/Anti-Inflammatory Agents; 0/Flavonoids; 0/Flavonols; 0/Plant Extracts; 0/quercetin-3-methylether; EC Elastase

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