Document Detail

Contribution of metabolites to mutagenicity during anaerobic biodegradation of fenitrothion.
MedLine Citation:
PMID:  12656246     Owner:  NLM     Status:  MEDLINE    
The contribution of fenitrothion and its microbial metabolites to the mutagenicity of a fenitrothion-containing solution was investigated during anaerobic biodegradation. Although a mixed culture of bacteria obtained from a paddy field degraded fenitrothion and reduced its concentration from 4.6 to 0.1 mg/l in 6 days, the indirect mutagenicity of the solution in Salmonella strain YG1029 increased. This increase was found to be partially due to amino-fenitrothion generated during the biodegradation. In addition, other unidentified metabolites contributed to the mutagenicity. In contrast, the indirect mutagenicity in strain YG1042, which was initially large because of fenitrothion, then decreased, and increased again. This increase in mutagenicity was also due to amino-fenitrothion and other unidentified metabolites. The mutagenicity in strains YG1029 and YG1042 decreased after day 6. The greatest contribution of amino-fenitrothion to the mutagenicity was calculated to be 73% and 61% in YG1029 and YG1042 on day 3 of incubation, respectively. That of unidentified metabolites was calculated at 49% and 61% on day 20, respectively. Therefore, because not all the toxic metabolites of a compound can be identified, it is important to evaluate the toxicity of a whole solution in a bioassay such as the Ames assay rather than deducing the toxicity of the solution from the combined toxicities of known metabolites.
Taku Matsushita; Yoshihiko Matsui; Kazunori Ikeba; Takanobu Inoue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemosphere     Volume:  50     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-82     Citation Subset:  IM    
Department of Civil Engineering, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan.
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MeSH Terms
Biodegradation, Environmental
Fenitrothion / metabolism,  toxicity*
Insecticides / metabolism,  toxicity*
Mutagenicity Tests
Mutagens / metabolism,  toxicity*
Salmonella typhimurium / genetics
Reg. No./Substance:
0/Insecticides; 0/Mutagens; 122-14-5/Fenitrothion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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