| Contribution of inadequate arterial remodeling to the development of focal coronary artery stenoses. An intravascular ultrasound study. | |
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MedLine Citation:
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PMID: 9107165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adaptive remodeling occurs to compensate for the accumulation of atherosclerotic plaque. Lumen reduction depends on the relative rates of plaque deposition and adaptive remodeling responses. Intravascular ultrasound permits detailed, high-quality, cross-sectional imaging of the coronary arteries in vivo. METHODS AND RESULTS: Preintervention intravascular ultrasound was used to study 603 focal, new, nonostial significant coronary artery stenoses in patients with chronic stable angina. Measurements of the target lesion of the external elastic membrane (EEM), lumen, and plaque plus media (P&M; P&M = EEM - Lumen) cross-sectional areas (CSAs) were compared with a proximal reference segment (most normal-looking cross section within 10 mm proximal to the lesion but distal to any side branch). Inadequate remodeling was defined as lesion/ reference EEM CSA that exceeded the upper limits of normal arterial tapering (lesion/reference EEM CSA ratio < or = 0.78 or a 21% reduction in EEM CSA per 10-mm length). Overall, the lesion/reference EEM CSA ratio was 1.00 +/- 0.22; 15% of lesions had inadequate remodeling, and 37% of the 603 lesions had less plaque than expected. This represented a lesion-specific response. The only predictor of inadequate remodeling was the arc of superficial lesion calcium. CONCLUSIONS: Inadequate remodeling is present in at least 15% of chronic, focal, new coronary arterial stenoses in patients with stable angina. The magnitude of arterial remodeling appears to be a lesion-specific response. |
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Authors:
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G S Mintz; K M Kent; A D Pichard; L F Satler; J J Popma; M B Leon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 95 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-05-13 Completed Date: 1997-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1791-8 Citation Subset: AIM; IM |
Affiliation:
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Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, DC 20010, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Aged Angina Pectoris / etiology Arteriosclerosis / complications, epidemiology, physiopathology*, radiography, ultrasonography Calcinosis / etiology, ultrasonography Cineangiography Coronary Angiography Coronary Disease / etiology, physiopathology*, radiography, ultrasonography Female Heart Catheterization Humans Male Middle Aged Nitroglycerin / administration & dosage Risk Factors |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin |
| Comments/Corrections | |
Comment In:
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Circulation. 1998 Apr 14;97(14):1424-5
[PMID:
9577957
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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