Document Detail


Contribution of in-vitro maturation in ovarian stimulation cycles of poor-responder patients.
MedLine Citation:
PMID:  20117048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This cohort study evaluated whether rescue spontaneous maturation (RSM) could be a valid method to increase the number of embryos available for transfer and whether transfers with RSM-derived embryos would contribute to clinical outcomes of poor-responder patients in ovarian stimulation cycles. The study included 440 patients undergoing intracytoplasmic sperm injection cycles in which fewer than five metaphase II (MII) oocytes and at least one immature oocyte were retrieved after follicle aspiration. Patients were allocated into two groups based on the injected oocytes' nuclear maturation status: MII group (n=330), in which only embryos derived from MII oocytes were transferred, and RSM group (n=110), in which at least one embryo derived from an RSM oocyte was transferred. No differences between the MII and RSM groups were observed for pregnancy (16.7% versus 16.5%) or miscarriage (25.5% versus 29.4%) rates, respectively. The RSM group had a higher number of transferred embryos (1.87+/-1.24 versus 2.35+/-1.22; P<0.001), a lower embryo transfer cancellation rate (14.5% versus 6.36%; P=0.025) and lower implantation rate (15.4+/-31.5% versus 10.5+/-22.3%; not significant). These findings suggest that RSM did not contribute to the outcomes in poor-responder cycles.
Authors:
Daniela Paes de Almeida Ferreira Braga; Rita de Cássia Sávio Figueira; Renata Cristina Ferreira; Fabio Firmbach Pasqualotto; Assumpto Iaconelli; Edson Borges
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Publication Detail:
Type:  Journal Article     Date:  2009-12-16
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  20     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-40     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, São Paulo 01402-001, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Embryo Implantation
Embryo Transfer
Female
Fertilization / physiology
Humans
Metaphase / physiology*
Oocytes / physiology*
Ovulation Induction / methods*
Pregnancy
Pregnancy Rate
Sperm Injections, Intracytoplasmic / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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