Document Detail

Contribution of hemodynamic variables to the lowering of blood pressure by substance P in the anesthetized rat.
MedLine Citation:
PMID:  8836448     Owner:  NLM     Status:  MEDLINE    
The radioactive microsphere technique was used to determine the contribution of acute changes in systemic hemodynamic variables to the lowering of blood pressure caused by substance P in rats anesthetized with urethane. Infusion of 0.74 nmol/kg/min of substance P caused a decrease of blood pressure, cardiac output, stroke volume and blood flow to most tissues. Total and regional vascular resistances were not affected. Heart rate was increased. These results suggest that the lowering of blood pressure caused by substance P occurs as a result of the decreased stroke volume and cardiac output. The most likely explanation for the decreased stroke volume is a decreased venous return. Several studies have shown that substance P has a direct effect to dilate peripheral arteries. Since substance P dilates arteries, one would expect a decrease of peripheral vascular resistance. The results of this study suggest, however, that counter-regulatory processes, elicited in response to the vasodilatation and direct effects of substance P on sympathetic ganglia to increase the sympathetic nervous system activity, offset the direct effect of substance P on arteries that would otherwise cause a decrease of peripheral vascular resistance.
J C Hancock; D B Hoover; R H Orcutt; T W Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  330     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1995 Nov-Dec
Date Detail:
Created Date:  1997-01-24     Completed Date:  1997-01-24     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  288-96     Citation Subset:  IM    
Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA.
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MeSH Terms
Blood Pressure / drug effects*
Cardiac Output / drug effects
Infusion Pumps
Infusions, Intravenous
Rats, Sprague-Dawley
Regional Blood Flow / drug effects
Stroke Volume / drug effects
Substance P / administration & dosage,  pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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