Document Detail


Contribution of gastric and postgastric feedback to satiation and satiety in women.
MedLine Citation:
PMID:  9333209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two parallel preload studies were conducted to determine the relative contributions of inhibitory feedback from the stomach and intestine to satiation (meal termination) and postprandial satiety. In the Gastric Emptying Study, five normal-weight women each ingested an egg sandwich (307 kcal) (1) immediately after a tomato soup preload (120 kcal), (2) 20 min after a tomato soup preload, and (3) with no preload. There was 125 g more of soup in the stomach when subjects began ingesting the sandwich immediately compared to 20 min after the soup, and the emptying of the sandwich was delayed when it was ingested immediately but not 20 min after the soup. The lag times for emptying of the sandwich were 76.5 (69.1-82.4), 47.2 (20.1-67.7), and 42.4 (17.8-65.1) min for the three conditions, respectively, p < 0.05. In the Food Intake Study, 16 normal-weight women ate significantly less (p < 0.01) in test meals offered immediately (978+/-246 kcal) and 20 min (1027+/-298 kcal) after the soup preload than in a test meal with no preload (1151+/-279 kcal). Despite the different amounts of soup in the stomach, subjects' test-meal intake in the two preload conditions was not significantly different. Subjects' fullness ratings following the preloads and the test meals were not different among the treatment conditions. The results suggest that feedback from neither the gastric nor the postgastric compartment is primary in determining meal size and postprandial satiety. Instead, signals from gastric and postgastric sources are combined to determine meal size and postprandial satiety.
Authors:
T A Spiegel; C D Hubert; H Fried; S R Peikin; J A Siegel; L S Zeiger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  62     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1125-36     Citation Subset:  IM    
Affiliation:
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey and Cooper Hospital/University Medical Center, Camden, NJ 08103, USA. spiegel@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Energy Intake / physiology
Feedback / physiology*
Female
Gastric Emptying / physiology*
Humans
Hunger / physiology
Intestines / innervation*
Mechanoreceptors / physiology
Neural Inhibition / physiology
Reference Values
Satiation / physiology*
Satiety Response / physiology*
Stomach / innervation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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