Document Detail


Contribution of the functional 5-HTTLPR variant of the SLC6A4 gene to obesity risk in male adults.
MedLine Citation:
PMID:  18239665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) gene SLC6A4 shows functionally important 44-bp insertion/deletion alleles: long (L) and short (S). We have previously found that the S allele is a genetic risk factor for obesity in adolescents. OBJECTIVE: The aim of this study was to evaluate whether the S/L variant of the SLC6A4 gene is associated with BMI as a continuous trait and also with obesity in a large sample of adult men of European ancestry included in a cross-sectional, population-based study. METHODS AND PROCEDURES: The study group was composed of individuals who were randomly recruited from a factory in the Buenos Aires metropolitan area and who underwent an annual health examination. RESULTS: We observed that among 1,329 unrelated subjects, aged 34.6 +/- 0.3 years, age-adjusted BMI values (expressed as mean +/- s.e.) for each genotype showed statistically significant differences across genotypic groups (LL: 25.4 +/- 0.2, LS: 26.0 +/- 0.1 and SS: 26.7 +/- 0.2, P < 0.0002). In addition, association tests showed that the 5-HTTLPR-genotype distribution was significantly different between 692 lean (BMI < or = 25 kg/m2) and 637 obese (BMI > or = 27 kg/m2) individuals. We found a 1.36 odds ratio (OR) (95% CI 1.01-1.85) for obesity in SS carriers in comparison with LL carriers, P = 0.026. DISCUSSION: In conclusion, our findings indicate that 5-HTTLPR polymorphism may be linked with BMI and also with obesity and/or overweight in adult male population, reinforcing the role of the serotonin transporter as a risk factor for the obesity phenotype and suggesting potential new avenues for its pharmacological treatment.
Authors:
Silvia Sookoian; Tomas F Gianotti; Carolina Gemma; Adriana Burgueño; Carlos J Pirola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  16     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-91     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, A Lanari, University of Buenos Aires-CONICET, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Body Mass Index
Case-Control Studies
Cross-Sectional Studies
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Male
Obesity / genetics*
Polymorphism, Genetic / genetics*
Receptors, Serotonin / genetics
Risk Factors
Serotonin Plasma Membrane Transport Proteins / genetics*
Chemical
Reg. No./Substance:
0/Receptors, Serotonin; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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