Document Detail

Contribution of fetal tricuspid regurgitation in first-trimester screening for major cardiac defects.
MedLine Citation:
PMID:  21606749     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : To estimate the potential value of fetal assessment for tricuspid regurgitation at 11-13 weeks of gestation in the prediction of major cardiac defects.
METHODS: : We screened for aneuploidies by measuring fetal nuchal translucency thickness as well as assessing blood flow across the tricuspid valve for evidence of tricuspid regurgitation and in the ductus venosus for evidence of reversed A-wave at 11 0/7 to13 6/7 weeks of gestation. The estimated performance of different combinations of increased fetal nuchal translucency, tricuspid regurgitation, and ductus venosus reversed A-wave in screening for major cardiac defects was examined.
RESULTS: : The study population of euploid fetuses included 85 cases with major cardiac defects and 40,905 with no cardiac defects. Fetal nuchal translucency above the 95th percentile, tricuspid regurgitation, or ductus venosus reversed A-wave was observed in 30 (35.3%), 28 (32.9%), and 24 (28.2%) of the fetuses with cardiac defects, respectively, and in 1,956 (4.8%), 516 (1.3%), and 856 (2.1%) of those without cardiac defects. Any one of the three markers was found in 49 of the fetuses with cardiac defects (57.6%, 95% confidence interval [CI] 47.0-67.6%) and in 3,265 of those without cardiac defects (8.0%, 95% CI 7.7-8.2%).
CONCLUSION: : Assessment of flow across the tricuspid valve improves the performance of screening for major cardiac defects by fetal nuchal translucency and ductus venosus flow.
Susana Pereira; Ramesh Ganapathy; Argyro Syngelaki; Nerea Maiz; Kypros H Nicolaides
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  117     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1384-91     Citation Subset:  AIM; IM    
From the Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, United Kingdom; the Department of Fetal Medicine, Medway Maritime Hospital, Gillingham, United Kingdom; Unidad Medicina Fetal, Centro Sanitario Virgen del Pilar, San Sebastián, Spain; and the Department of Fetal Medicine, University College Hospital, London, United Kingdom.
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