| Contribution of ferrous iron to maintenance of the gastric colonization of Helicobacter pylori in miniature pigs. | |
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MedLine Citation:
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PMID: 12501997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our previous study showed that the colonization levels of Helicobacter pylori were higher in the stomachs of 5-day-old miniature pigs than in 2-week-old ones. As dietary factors can cause these differences, we compared two diets, i.e., Weanymilk and a similar formula with a higher concentration of Fe(II), Weanylobulin. The colonization levels in the fundic mucosa were significantly higher in 2-week-old pigs fed Weanylobulin than in those fed Weanymilk. Supplementing Weanylobulin with an iron chelator, deferoxamine mesylate, significantly lowered the bacteria counts in the gastric mucosa. Normal diets supplemented with Fe(II) in 2-month-old pigs caused significantly more sites of bacteria in the antrum compared with normal diets alone. In addition, ranitidine, an inhibitor of gastric acid secretion that reduces Fe(III) to Fe(II) in the stomach, decreased the bacteria counts in 10-month-old pigs. These results suggested that Fe(II) maintained the colonization levels of H. pylori in the stomach of the miniature pigs. |
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Authors:
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Tetsufumi Koga; Yukio Shimada; Kiyoshi Sato; Keigo Takahashi; Isamu Kikuchi; Yoko Okazaki; Tomoko Miura; Mitsuo Katsuta; Masayuki Iwata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microbiological research Volume: 157 ISSN: 0944-5013 ISO Abbreviation: Microbiol. Res. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-12-27 Completed Date: 2003-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9437794 Medline TA: Microbiol Res Country: Germany |
Other Details:
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Languages: eng Pagination: 323-30 Citation Subset: IM |
Affiliation:
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Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo, Japan. tekoga@shina.sankyo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colony Count, Microbial Deferoxamine / pharmacology Ferrous Compounds / pharmacology* Gastric Mucosa / microbiology* Helicobacter pylori / growth & development* Iron-Dextran Complex / pharmacology Male Ranitidine / pharmacology Swine Swine, Miniature |
| Chemical | |
Reg. No./Substance:
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0/Ferrous Compounds; 66357-35-5/Ranitidine; 70-51-9/Deferoxamine; 9004-66-4/Iron-Dextran Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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