| Contribution of erythrocytes to the control of the electrolyte changes of exercise. | |
| | |
MedLine Citation:
|
PMID: 1954568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Five healthy males performed four 30-s bouts of maximal isokinetic cycling with 4 min rest between each bout. Arterial and femoral venous blood was sampled during and for 90 min following exercise. During exercise, arterial erythrocyte [K+] increased from 117.0 +/- 6.6 mequiv./L at rest to 124.2 +/- 5.9 mequiv./L after the second exercise bout. Arterial erythrocyte [K+] returned to the resting values during the first 5 min of recovery. No significant change was observed in femoral venous erythrocyte [K+]. Arterial erythrocyte lactate concentration ([Lac-]) increased during exercise from 0.2 +/- 0.1 mequiv./L peaking at 9.5 +/- 1.5 mequiv./L at 5 min of recovery, after which the values returned to control. Femoral venous erythrocyte [Lac-] changed in a similar fashion. Arterial erythrocyte [Cl-] rose during exercise to 76 +/- 3 mequiv./L and returned to resting values (70 +/- 2 mequiv./L) by 25 min recovery. During exercise there was a net flux of Cl- into the erythrocyte. We conclude that erythrocytes are a sink for K+ ions leaving working muscles. Furthermore, erythrocytes function to transport Lac- from working muscle and reduce plasma acidosis by uptake of Cl-. The erythrocyte uptake of K+, Lac-, and Cl- helps to maintain a concentration difference between plasma and muscle, facilitating diffusion of Lac- and K+ from the interstitial space into femoral venous plasma. |
| | |
Authors:
|
R S McKelvie; M I Lindinger; G J Heigenhauser; N L Jones |
Related Documents
:
|
7636388 - The effect of cell-free hemoglobin on intravascular clearance and cellular, plasma, and... 719168 - Variability of the homeostatic response to altered p50. 18971378 - Multiple regulatory steps control mammalian nonmuscle myosin ii assembly in live cells. 3797628 - Role of water and ethanol radicals in the radiation destruction of human deoxyhemoglobin. 7563388 - The effect of extracorporeal electromagnetic shock waves on the morphology and contract... 18401118 - First report of cryptosporidium spp. oocysts in oysters (crassostrea rhizophorae) and c... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Canadian journal of physiology and pharmacology Volume: 69 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1991 Jul |
Date Detail:
|
Created Date: 1991-12-30 Completed Date: 1991-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 984-93 Citation Subset: IM |
Affiliation:
|
Ambrose Cardiorespiratory Unit, McMaster University Health Sciences Centre, Hamilton, Ont., Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acid-Base Equilibrium
/
physiology Acidosis / blood Adult Chlorides / blood Electrolytes / blood* Erythrocytes / physiology* Exercise / physiology* Hematocrit Humans Lactates / blood Male Potassium / blood Sodium / blood |
| Chemical | |
Reg. No./Substance:
|
0/Chlorides; 0/Electrolytes; 0/Lactates; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Arterial adaptations to altered blood flow.
Next Document: Production and characterization of murine monoclonal antibodies against staphylococcal enterotoxins ...