Document Detail


Contribution of erythrocytes to the control of the electrolyte changes of exercise.
MedLine Citation:
PMID:  1954568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five healthy males performed four 30-s bouts of maximal isokinetic cycling with 4 min rest between each bout. Arterial and femoral venous blood was sampled during and for 90 min following exercise. During exercise, arterial erythrocyte [K+] increased from 117.0 +/- 6.6 mequiv./L at rest to 124.2 +/- 5.9 mequiv./L after the second exercise bout. Arterial erythrocyte [K+] returned to the resting values during the first 5 min of recovery. No significant change was observed in femoral venous erythrocyte [K+]. Arterial erythrocyte lactate concentration ([Lac-]) increased during exercise from 0.2 +/- 0.1 mequiv./L peaking at 9.5 +/- 1.5 mequiv./L at 5 min of recovery, after which the values returned to control. Femoral venous erythrocyte [Lac-] changed in a similar fashion. Arterial erythrocyte [Cl-] rose during exercise to 76 +/- 3 mequiv./L and returned to resting values (70 +/- 2 mequiv./L) by 25 min recovery. During exercise there was a net flux of Cl- into the erythrocyte. We conclude that erythrocytes are a sink for K+ ions leaving working muscles. Furthermore, erythrocytes function to transport Lac- from working muscle and reduce plasma acidosis by uptake of Cl-. The erythrocyte uptake of K+, Lac-, and Cl- helps to maintain a concentration difference between plasma and muscle, facilitating diffusion of Lac- and K+ from the interstitial space into femoral venous plasma.
Authors:
R S McKelvie; M I Lindinger; G J Heigenhauser; N L Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  69     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  984-93     Citation Subset:  IM    
Affiliation:
Ambrose Cardiorespiratory Unit, McMaster University Health Sciences Centre, Hamilton, Ont., Canada.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium / physiology
Acidosis / blood
Adult
Chlorides / blood
Electrolytes / blood*
Erythrocytes / physiology*
Exercise / physiology*
Hematocrit
Humans
Lactates / blood
Male
Potassium / blood
Sodium / blood
Chemical
Reg. No./Substance:
0/Chlorides; 0/Electrolytes; 0/Lactates; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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