| Contribution of endothelium-derived nitric oxide to coronary arterial distensibility: an in vivo two-dimensional intravascular ultrasound study. | |
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MedLine Citation:
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PMID: 7900624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reduced epicardial coronary arterial distensibility associated with early atherosclerosis may be mediated in part by reduced nitric oxide (NO) release. To directly assess the contribution of endogenous NO to coronary arterial distensibility, we examined the effect of intracoronary N omega nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase, and L-arginine, its natural substrate, on the circumflex artery in seven anesthetized dogs. We also used intracoronary acetylcholine to examine the effect of pharmacologically induced NO release on coronary distensibility. Electrocardiographically gated measurements of epicardial coronary lumen area were made by a blinded observer from images obtained with a 4.3F, 30 MHz intravascular ultrasound catheter. Aortic root pressure was continuously monitored, and neither systemic arterial pressure nor pulse pressure changed significantly with intracoronary drug administration. Change in lumen area (delta LA) from end systole to end diastole was measured, and an arterial distensibility index was calculated. Delta LA increased with acetylcholine from 8.2% +/- 0.5% at baseline to 16.3% +/- 2.8% (10(-6) mol/L; p < 0.001), with increases in both end-systolic and end-diastolic lumen area and decreased delta LA to 3.1% +/- 1.3% (p < 0.01). Lumen area and delta LA were both restored to baseline by L-arginine (10(-4)). The calculated distensibility index of the epicardial coronary artery was enhanced by acetylcholine, reduced below baseline by L-NAME, and restored to baseline by L-arginine.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K Sudhir; W L Mullen; D Hausmann; P J Fitzgerald; T M Chou; P G Yock; K Chatterjee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 129 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-04-27 Completed Date: 1995-04-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 726-32 Citation Subset: AIM; IM |
Affiliation:
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Cardiovascular Research Institute, University of California, San Francisco. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Angioplasty, Transluminal, Percutaneous Coronary / adverse effects Animals Arginine / analogs & derivatives, pharmacology Coronary Vessels / drug effects, physiology*, ultrasonography* Dogs Endothelium, Vascular / drug effects, injuries NG-Nitroarginine Methyl Ester Nitric Oxide / antagonists & inhibitors, physiology* Nitroglycerin / pharmacology Ultrasonography, Interventional / methods* Vascular Resistance / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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