Document Detail

Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants.
MedLine Citation:
PMID:  21415837     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study is to investigate the relationship between glycemic status and severe retinopathy of prematurity (ROP).
STUDY DESIGN: This is a retrospective cohort study of 114 infants <1000 g admitted to a level IV neonatal intensive care unit within 48 h of life. A cumulative, time-weighted glucose level (TWGL) derived from plotting glucose values over time was included in logistic regression analysis to identify predictors for severe ROP.
RESULT: Infants had 26.6 ± 2 weeks gestational age and had a birth weight of 782 ± 136 g. TWGL during first 10 and 30 days of life were greater in the severe ROP group (P<0.01). Unlike single events of glucose levels ≥ 150 mg dl(-1), 10 days TWGL ≥ 100 mg dl(-1) (odds ratio (OR) 5.2, P<0.02) and 30 days TWGL ≥ 118 mg dl(-1) (OR 5.7, P<0.02) were predictors for severe ROP (univariate). Multivariate regression confirmed 30 days TWGL ≥ 118 mg dl(-1) (OR 9.4 to 10) and gram-positive sepsis (OR 4.1 to 5) as predictors for severe ROP (P<0.05).
CONCLUSION: High overall glycemic status is associated with the development of severe ROP.
R Chavez-Valdez; J McGowan; E Cannon; C U Lehmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-17
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  31     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-29     Completed Date:  2012-03-29     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  749-56     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / analysis*
Infant, Extremely Low Birth Weight*
Infant, Newborn
Infant, Premature
Retinopathy of Prematurity / blood*,  complications,  therapy
Reg. No./Substance:
0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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