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Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants.
MedLine Citation:
PMID:  21415837     Owner:  NLM     Status:  Publisher    
Objective:The objective of this study is to investigate the relationship between glycemic status and severe retinopathy of prematurity (ROP).Study Design:This is a retrospective cohort study of 114 infants <1000 g admitted to a level IV neonatal intensive care unit within 48 h of life. A cumulative, time-weighted glucose level (TWGL) derived from plotting glucose values over time was included in logistic regression analysis to identify predictors for severe ROP.Result:Infants had 26.6±2 weeks gestational age and had a birth weight of 782±136 g. TWGL during first 10 and 30 days of life were greater in the severe ROP group (P<0.01). Unlike single events of glucose levels 150 mg dl(-1), 10 days TWGL 100 mg dl(-1) (odds ratio (OR) 5.2, P<0.02) and 30 days TWGL 118 mg dl(-1) (OR 5.7, P<0.02) were predictors for severe ROP (univariate). Multivariate regression confirmed 30 days TWGL 118 mg dl(-1) (OR 9.4 to 10) and gram-positive sepsis (OR 4.1 to 5) as predictors for severe ROP (P<0.05).Conclusion:High overall glycemic status is associated with the development of severe ROP.Journal of Perinatology advance online publication, 17 March 2011; doi:10.1038/jp.2011.19.
R Chavez-Valdez; J McGowan; E Cannon; C U Lehmann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-17
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] Division of Neonatology, Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX, USA [2] Division of Neonatology, Department of Pediatrics, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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