Document Detail


Contribution of donor and recipient characteristics to short- and long-term pancreas graft survival.
MedLine Citation:
PMID:  23274321     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many donor and recipient factors are known to affect pancreas graft survival. However, their relative importance in explaining differences in graft survival is unknown. Purpose of this study was to retrospectively evaluate the impact of donor and recipient factors on pancreas graft survival, and compare their contribution in explaining graft survival differences.
MATERIAL/METHODS: Patient records of all 170 pancreas transplantations (158 Simultaneous Pancreas-Kidney; 12 Pancreas-after-kidney) in the period 1997-2008 were reviewed retrospectively to assess recipient factors before/during transplantation, and to assess graft survival. Eurotransplant reports were reviewed to assess donor factors.
RESULTS: Death-censored 1-year graft survival was 88.4% and 82.3% at 3 years. Several factors significantly influenced graft survival: female recipient gender (Hazard Ratio (HR) 2.81[1.10-7.14]), enteric graft drainage (HR 2.85[1.15-7.05]), and donor-recipient match on BMI (HR 2.46[1.01-6.02]). None of the donor factors significantly affected survival. Similar results were found for 1-year survival, except for enteric graft drainage and donor-recipient BMI matching. In total, donor factors explained 3.6% and recipient factors 10.0% of the variance in graft survival. Donor factors were more important for 1-year survival (3.1%), but still less important than recipient factors which explained 6.4%.
CONCLUSIONS: Recipient factors are more important in explaining differences in pancreas graft survival than donor factors.
Authors:
Denise E Hilling; Andrzej G Baranski; Ada Haasnoot; Paul J M van der Boog; Onno T Terpstra; Perla J Marang-van de Mheen
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  17     ISSN:  2329-0358     ISO Abbreviation:  Ann. Transplant.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-05-28     Revised Date:  2013-06-17    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  28-38     Citation Subset:  IM    
Affiliation:
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Diabetes Mellitus, Type 1 / surgery*
Donor Selection
Female
Follow-Up Studies
Graft Survival*
Humans
Kaplan-Meier Estimate
Kidney Transplantation
Male
Middle Aged
Netherlands
Pancreas Transplantation*
Perioperative Care
Proportional Hazards Models
Retrospective Studies
Sex Factors
Tissue Donors* / statistics & numerical data
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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