| Contribution of the crystalline lens gradient refractive index to the accommodation amplitude in non-human primates: in vitro studies. | |
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MedLine Citation:
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PMID: 22131444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the contribution of the gradient refractive index to the change in lens power in hamadryas baboon and cynomolgus monkey lenses during simulated accommodation in a lens stretcher. Thirty-six monkey lenses (1.4-14.1 years) and twenty-five baboon lenses (1.8-28.0 years) were stretched in discrete steps. At each stretching step, the lens back vertex power was measured and the lens cross-section was imaged with optical coherence tomography. The radii of curvature for the lens anterior and posterior surfaces were calculated for each step. The power of each lens surface was determined using refractive indices of 1.365 for the outer cortex and 1.336 for the aqueous. The gradient contribution was calculated by subtracting the power of the surfaces from the measured lens power. In all lenses, the contribution of the surfaces and gradient increased linearly with the amplitude of accommodation. The gradient contributes on average 65 ± 3% for monkeys and 66 ± 3% for baboons to the total power change during accommodation. When expressed in percent of the total power change, the relative contribution of the gradient remains constant with accommodation and age in both species. These findings are consistent with Gullstrand's intracapsular theory of accommodation. |
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Authors:
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Bianca M Maceo; Fabrice Manns; David Borja; Derek Nankivil; Stephen Uhlhorn; Esdras Arrieta; Arthur Ho; Robert C Augusteyn; Jean-Marie Parel |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-30 |
Journal Detail:
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Title: Journal of vision Volume: 11 ISSN: 1534-7362 ISO Abbreviation: J Vis Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-01 Completed Date: 2012-04-03 Revised Date: 2013-01-09 |
Medline Journal Info:
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Nlm Unique ID: 101147197 Medline TA: J Vis Country: United States |
Other Details:
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Languages: eng Pagination: 23 Citation Subset: IM |
Affiliation:
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Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Accommodation, Ocular
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physiology* Aging / physiology Animals Lens, Crystalline / anatomy & histology, physiology* Macaca fascicularis* Papio hamadryas* Refraction, Ocular / physiology* Tomography, Optical Coherence |
| Grant Support | |
ID/Acronym/Agency:
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1F31EY021444/EY/NEI NIH HHS; 2R01EY14225/EY/NEI NIH HHS; 5F31EY15395/EY/NEI NIH HHS; F31 EY021444-01/EY/NEI NIH HHS; P30EY14801/EY/NEI NIH HHS |
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