Document Detail

Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents.
MedLine Citation:
PMID:  21528810     Owner:  NLM     Status:  MEDLINE    
The role of ACE gene insertion (I) or deletion (D) polymorphism on blood pressure phenotype is not clear in children. The aim of this work is to examine the association between hypertension and ACE I/D polymorphism, as well as the contribution of clinical and metabolic parameters on blood pressure. The study participants were 199 obese children. Forty-four of them were hypertensive. The hypertensive subjects were older than the normotensive and most of them were pubertal. The prevalence of hypertension in obese subjects with II, ID, and DD genotype was similar. There was no difference between the hypertensive and the normotensive group according to ACE I/D genotype, BMISDS, sex, blood glucose level and total cholesterol levels. In obese children, high IR-HOMA values, puberty, presence of family history for hypertension, hypertriglyceridemia, and low HDL-cholesterol, high triglyceride/HDL-cholesterol ratio were found as increased risk factors of hypertension. In obese children and adolescents, blood pressure did not differ by ACE I/D genotype. The presence of family history, puberty, insulin resistance and hypertriglyceridemia constitute important risk factors for developing hypertension.
Zeynep Siklar; Merih Berberoglu; Senay Savas Erdeve; Bülent Hacihamdioglu; Gönül Ocal; Yonca Egin; Nejat Akar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  24     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-05-31     Revised Date:  2012-01-10    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey.
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MeSH Terms
Age of Onset
Body Mass Index
Child, Preschool
Disease Susceptibility / metabolism
Genetic Predisposition to Disease
Hypertension / epidemiology,  etiology*,  genetics*,  metabolism*
Insulin Resistance / physiology
Obesity / complications*,  epidemiology,  genetics,  metabolism
Risk Factors

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