| Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents. | |
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MedLine Citation:
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PMID: 21528810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of ACE gene insertion (I) or deletion (D) polymorphism on blood pressure phenotype is not clear in children. The aim of this work is to examine the association between hypertension and ACE I/D polymorphism, as well as the contribution of clinical and metabolic parameters on blood pressure. The study participants were 199 obese children. Forty-four of them were hypertensive. The hypertensive subjects were older than the normotensive and most of them were pubertal. The prevalence of hypertension in obese subjects with II, ID, and DD genotype was similar. There was no difference between the hypertensive and the normotensive group according to ACE I/D genotype, BMISDS, sex, blood glucose level and total cholesterol levels. In obese children, high IR-HOMA values, puberty, presence of family history for hypertension, hypertriglyceridemia, and low HDL-cholesterol, high triglyceride/HDL-cholesterol ratio were found as increased risk factors of hypertension. In obese children and adolescents, blood pressure did not differ by ACE I/D genotype. The presence of family history, puberty, insulin resistance and hypertriglyceridemia constitute important risk factors for developing hypertension. |
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Authors:
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Zeynep Siklar; Merih Berberoglu; Senay Savas Erdeve; Bülent Hacihamdioglu; Gönül Ocal; Yonca Egin; Nejat Akar |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 24 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-05-31 Revised Date: 2012-01-10 |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Affiliation:
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Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey. zeynepsklr@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age of Onset Body Mass Index Child Child, Preschool Disease Susceptibility / metabolism Female Genetic Predisposition to Disease Humans Hypertension / epidemiology, etiology*, genetics*, metabolism* Infant Insulin Resistance / physiology Male Obesity / complications*, epidemiology, genetics, metabolism Prevalence Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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