| Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | |
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MedLine Citation:
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PMID: 21577274 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The development of cataract is associated with some lipid changes in human lens fibers, especially with increased accumulation and redistribution of cholesterol inside these cells. Some direct and indirect lines of evidence, also suggest an involvement of cholesterol oxide derivatives (also named oxysterols) in the development of cataract. Oxysterol formation can result either from nonenzymatic or enzymatic processes, and some oxysterols can induce a wide range of cytotoxic effects (overproduction of reactive oxygen species (ROS); phospholipidosis) which might contribute to the initiation and progression of cataract. Thus, the conception of molecules capable of regulating cholesterol homeostasia and oxysterol levels in human lens fibers can have some interests and constitute an alternative to surgery at least at early stages of the disease. |
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Authors:
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Anne Vejux; Mohammad Samadi; Gérard Lizard |
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Publication Detail:
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Type: Journal Article Date: 2011-04-04 |
Journal Detail:
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Title: Journal of ophthalmology Volume: 2011 ISSN: 2090-0058 ISO Abbreviation: J Ophthalmol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-17 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101524199 Medline TA: J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 471947 Citation Subset: - |
Affiliation:
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Inserm-CIT 808, CHU de Besançon, 25030 Besançon, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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