Document Detail

Contribution of captopril thiol group to the prevention of spontaneous hypertension.
MedLine Citation:
PMID:  17824808     Owner:  NLM     Status:  MEDLINE    
We aimed to compare the effect of angiotensin converting enzyme (ACE) inhibitors captopril (containing thiol group) and enalapril (without thiol group) on the development of spontaneous hypertension and to analyze mechanisms of their actions, particularly effects on oxidative stress and NO production. Six-week-old SHR were divided into three groups: control, group receiving captopril (50 mg/kg/day) or enalapril (50 mg/kg/day) for 6 weeks. At the end of experiment, systolic blood pressure (SBP) increased by 41 % in controls. Both captopril and enalapril prevented blood pressure increase, however, SBP in the captopril group (121+/-5 mmHg) was significantly lower than that in the enalapril group (140+/-5 mmHg). Concentration of conjugated dienes in the aorta was significantly lower in the captopril group compared to the enalapril group. Captopril and enalapril increased NO synthase activity in the heart and aorta to the similar level. Neither captopril nor enalapril was, however, able to increase the expression of eNOS. Both ACE inhibitors increased the level of cGMP. However, cGMP level was significantly higher in the aorta of captopril group. We conclude that captopril, beside inhibition of ACE, prevented hypertension by increasing NO synthase activity and by simultaneous decrease of oxidative stress which resulted in increase of cGMP concentration.
O Pechánová
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-05
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  56 Suppl 2     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S41-8     Citation Subset:  IM    
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*,  therapeutic use
Antihypertensive Agents / pharmacology*,  therapeutic use
Aorta / drug effects,  enzymology
Blood Pressure / drug effects
Captopril / pharmacology*,  therapeutic use
Cardiomegaly / etiology,  prevention & control
Cyclic GMP / metabolism
Disease Models, Animal
Enalapril / pharmacology*,  therapeutic use
Hypertension / complications,  genetics,  metabolism,  physiopathology,  prevention & control*
Myocytes, Cardiac / drug effects,  enzymology
Nitric Oxide / metabolism
Nitric Oxide Synthase / metabolism
Oxidative Stress / drug effects
Rats, Inbred SHR
Sulfhydryl Compounds / pharmacology*,  therapeutic use
Time Factors
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Sulfhydryl Compounds; 10102-43-9/Nitric Oxide; 62571-86-2/Captopril; 75847-73-3/Enalapril; 7665-99-8/Cyclic GMP; EC Oxide Synthase

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