Document Detail

Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats.
MedLine Citation:
PMID:  14508204     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It has been proposed that blood pressure variability (BPV) is positively related to end-organ damage (EOD) in hypertension. The present work was designed to observe the effects of long-term treatment with nitrendipine and hydralazine on BPV and EOD in spontaneously hypertensive rats (SHR), to examine the hypothesis that lowering BPV with an antihypertensive drug is an important factor in organ protection. DESIGN AND METHODS: Drugs were mixed in rat chow. After 4 months of drug administration, blood pressure was recorded continuously in conscious freely moving rats for 24 h. The heart, kidneys, and brain were then isolated and examined. RESULTS: It was found that nitrendipine significantly decreased blood pressure and BPV, and significantly decreased EOD score in SHR. Hydralazine decreased blood pressure, but did not lower BPV. No effect on EOD was found in hydralazine-treated rats. In control rats (n = 38), EOD score was weakly related to systolic blood pressure (r = 0.331, P < 0.05) and closely related to long-term systolic BPV (r = 0.551, P < 0.01). In nitrendipine-treated rats, EOD score was closely related to long-term systolic BPV (r = 0.602, P < 0.01), but not to BP level (r = 0.174, P > 0.05). CONCLUSION: BPV plays an important role in the organ-protecting effects of nitrendipine.
Jian-Guo Liu; Li-Ping Xu; Zheng-Xu Chu; Chao-Yu Miao; Ding-Feng Su
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  21     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-25     Completed Date:  2004-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1961-7     Citation Subset:  IM    
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects,  physiology*
Drug Therapy, Combination
Hydralazine / pharmacology
Hypertension / drug therapy*,  pathology,  physiopathology
Linear Models
Nitrendipine / pharmacology*
Rats, Inbred SHR
Reg. No./Substance:
0/Antihypertensive Agents; 39562-70-4/Nitrendipine; 86-54-4/Hydralazine
Comment In:
J Hypertens. 2003 Oct;21(10):1827-30   [PMID:  14508187 ]

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