Document Detail


Contribution of beta-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS).
MedLine Citation:
PMID:  12738677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prospective analysis of the importance of the plasma levels of beta-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS.
Authors:
Simona Gatto; Greg Ball; Francesco Onida; Hagop M Kantarjian; Elihu H Estey; Miloslav Beran
Related Documents :
3966697 - Pulmonary cavitation and massive hemoptysis in invasive pulmonary aspergillosis. influe...
15370217 - Subdural hematomas during cml therapy with imatinib mesylate.
9368477 - Prognostic significance of dysplastic features of hematopoiesis in patients with de nov...
2615527 - Coexistent chronic lymphocytic leukemia and polycythemia vera requiring no treatment.
2088587 - Use of the captopril test to assess renin responsiveness in children with hypertension ...
21772877 - New interpretation for diagnostic yield of ileoscopy: a prospective study and a brief r...
Publication Detail:
Type:  Journal Article     Date:  2003-05-08
Journal Detail:
Title:  Blood     Volume:  102     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-21     Completed Date:  2003-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1622-5     Citation Subset:  AIM; IM    
Affiliation:
M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 428, Houston, TX 77030, USA. mberan@mdanderson.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
Humans
Male
Middle Aged
Myelodysplastic Syndromes / blood*,  diagnosis,  mortality*
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Factors
Survival Analysis
beta 2-Microglobulin / blood*
Chemical
Reg. No./Substance:
0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood trans...
Next Document:  Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor ...