Document Detail

Contribution of beta-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS).
MedLine Citation:
PMID:  12738677     Owner:  NLM     Status:  MEDLINE    
Prospective analysis of the importance of the plasma levels of beta-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS.
Simona Gatto; Greg Ball; Francesco Onida; Hagop M Kantarjian; Elihu H Estey; Miloslav Beran
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Publication Detail:
Type:  Journal Article     Date:  2003-05-08
Journal Detail:
Title:  Blood     Volume:  102     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-21     Completed Date:  2003-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1622-5     Citation Subset:  AIM; IM    
M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 428, Houston, TX 77030, USA.
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MeSH Terms
Middle Aged
Myelodysplastic Syndromes / blood*,  diagnosis,  mortality*
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Risk Factors
Survival Analysis
beta 2-Microglobulin / blood*
Reg. No./Substance:
0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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