Document Detail

Contribution of baseline body mass index and leptin serum level to the prediction of early weight gain with atypical antipsychotics in schizophrenia.
MedLine Citation:
PMID:  24552633     Owner:  NLM     Status:  In-Data-Review    
AIM: This study investigated whether biochemical parameters add predictive information concerning risk for weight gain associated with treatment with atypical antipsychotics (AP) to that provided by baseline weight.
METHODS: Weight changes were assessed in 25 patients with schizophrenia after 3-6 months of treatment. These patients were started on AP monotherapy owing to a first psychotic episode or resumed treatment after at least a 6-month period of abandonment. Anthropometric and biochemical data were collected and analyzed as predictors of early weight change.
RESULTS: The baseline biochemical and anthropometric data were not significantly higher in the patients than in the healthy participants. During follow up, the patients had significant increases in body mass index and total cholesterol and apolipoprotein B level. The baseline weight and leptin level were predictive of weight gain during follow up, with an inverse association in both cases.
CONCLUSION: Baseline weight and leptin level may help to assess the risk of early weight gain with AP.
Benjamín Cortés; Joemir Bécker; María Teresa Mories Álvarez; Ana I Sánchez Marcos; Vicente Molina
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Publication Detail:
Type:  Journal Article     Date:  2013-10-31
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  68     ISSN:  1440-1819     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology.
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