Document Detail

Contribution of the baroreflex afferent nerves to the production of vasoconstricted hypertension in volume-expanded dogs.
MedLine Citation:
PMID:  2573437     Owner:  NLM     Status:  MEDLINE    
Dextran in lactated Ringer's solution (20 ml/kg) was infused for 1 hour into anesthetized dogs with sinoaortic denervation and vagotomy (deafferentation; n = 10) and dogs treated with hexamethonium (de-efferentation; n = 13) to compare with our previous observation in dogs with an intact autonomic nervous system (control, n = 34). During the infusion, increase in blood pressure associated with increase in cardiac output was observed in all three groups. The increases in blood pressure were larger in the two groups with an impaired autonomic nervous system. In the recovery period, the control dogs and the hexamethonium-treated dogs showed gradual increases in total peripheral resistance and in vasoconstricted hypertension 3 hours after stopping the infusion. In contrast, the dogs with sinoaortic denervation and vagotomy did not show any increase in total peripheral resistance. The vasoconstricted groups showed peaks of natriuresis soon after the infusion, not 3 hours after the infusion when vasoconstriction was observed, although the dogs with deafferentation did not show a significant increase in natriuresis. Norepinephrine (0.5 micrograms/kg) was administered intravenously before and after volume expansion, and the pressor responses in the three groups after volume expansion were enhanced similarly (143%, 128%, and 136%, respectively). These results indicate that the afferent signals from peripheral vessels to the brain contribute to the production of vasoconstricted hypertension after acute volume expansion and that the vasoconstriction is independent of pressor hypersensitivity and is dissociated in time from the natriuresis.
A Otsuka; T Ogihara; H Mikami; K Kohara; K Katahira; T Tsunetoshi; Y Kumahara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation research     Volume:  65     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-11     Completed Date:  1990-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1467-74     Citation Subset:  IM    
Department of Geriatric Medicine, Osaka University Medical School, Japan.
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MeSH Terms
Afferent Pathways
Blood Pressure / drug effects
Blood Volume
Hexamethonium Compounds / pharmacology
Hypertension / physiopathology*
Norepinephrine / pharmacology
Pressoreceptors / physiology*
Reflex / physiology
Vagus Nerve / physiology*
Reg. No./Substance:
0/Hexamethonium Compounds; 51-41-2/Norepinephrine; 60-26-4/Hexamethonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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