Document Detail

Contribution of β-adrenergic receptors to exercise-induced bronchodilatation in healthy humans.
MedLine Citation:
PMID:  22842007     Owner:  NLM     Status:  MEDLINE    
Exercise in healthy subjects is usually associated with progressive bronchodilatation. Though the decrease in vagal tone is deemed to be the main underlying mechanism, activation of bronchial β(2)-receptors may constitute an additional cause. To examine the contribution of β(2)-adrenergic receptors to bronchodilatation during exercise in healthy humans, we studied 15 healthy male volunteers during maximum exercise test at control conditions and after a non-selective β-adrenergic blocker (carvedilol 12.5mg twice a day until heart rate decreased at least by 10beats/min) and inhaled β(2)-agonist (albuterol 400μg). Airway caliber was estimated from the partial flow at 40% of control forced vital capacity (V˙(part40)) and its changes during exercise from the slope of linear regression analysis of V˙(part40) values against the corresponding minute ventilation during maximal exercise until exhaustion. At control, V˙(part40) increased progressively and significantly with exercise. After albuterol, resting V˙(part40) was significantly larger than at control increased but did not further increase during exercise. After carvedilol, V˙(part40) was similar to control but its increase with exercise was significantly attenuated. These findings suggest that β(2)-adrenergic system plays a major role in exercise-induced bronchodilation in healthy subjects.
Andrea Antonelli; Roberto Torchio; Luca Bertolaccini; Alberto Terzi; Fabrizio Rolfo; Piergiuseppe Agostoni; Carlo Gulotta; Vito Brusasco; Riccardo Pellegrino
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Publication Detail:
Type:  Journal Article     Date:  2012-07-25
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  184     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-04-22     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Allergologia, Fisiopatologia Respiratoria, ASO S. Croce e Carle, 12100 Cuneo, Italy.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Albuterol / pharmacology
Bronchodilator Agents / pharmacology
Carbazoles / pharmacology
Exercise / physiology*
Exercise Test
Middle Aged
Muscle Tonus / drug effects,  physiology
Muscle, Smooth / drug effects,  physiology
Propanolamines / pharmacology
Pulmonary Ventilation / drug effects,  physiology*
Receptors, Adrenergic, beta / metabolism*
Respiratory Function Tests
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Bronchodilator Agents; 0/Carbazoles; 0/Propanolamines; 0/Receptors, Adrenergic, beta; 0K47UL67F2/carvedilol; 18559-94-9/Albuterol

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