| Contribution of β-adrenergic receptors to exercise-induced bronchodilatation in healthy humans. | |
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MedLine Citation:
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PMID: 22842007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise in healthy subjects is usually associated with progressive bronchodilatation. Though the decrease in vagal tone is deemed to be the main underlying mechanism, activation of bronchial β(2)-receptors may constitute an additional cause. To examine the contribution of β(2)-adrenergic receptors to bronchodilatation during exercise in healthy humans, we studied 15 healthy male volunteers during maximum exercise test at control conditions and after a non-selective β-adrenergic blocker (carvedilol 12.5mg twice a day until heart rate decreased at least by 10beats/min) and inhaled β(2)-agonist (albuterol 400μg). Airway caliber was estimated from the partial flow at 40% of control forced vital capacity (V˙(part40)) and its changes during exercise from the slope of linear regression analysis of V˙(part40) values against the corresponding minute ventilation during maximal exercise until exhaustion. At control, V˙(part40) increased progressively and significantly with exercise. After albuterol, resting V˙(part40) was significantly larger than at control increased but did not further increase during exercise. After carvedilol, V˙(part40) was similar to control but its increase with exercise was significantly attenuated. These findings suggest that β(2)-adrenergic system plays a major role in exercise-induced bronchodilation in healthy subjects. |
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Authors:
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Andrea Antonelli; Roberto Torchio; Luca Bertolaccini; Alberto Terzi; Fabrizio Rolfo; Piergiuseppe Agostoni; Carlo Gulotta; Vito Brusasco; Riccardo Pellegrino |
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Publication Detail:
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Type: Journal Article Date: 2012-07-25 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 184 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-02 Completed Date: 2013-04-22 Revised Date: 2013-05-28 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 55-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Allergologia, Fisiopatologia Respiratoria, ASO S. Croce e Carle, 12100 Cuneo, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Albuterol / pharmacology Bronchodilator Agents / pharmacology Carbazoles / pharmacology Exercise / physiology* Exercise Test Humans Male Middle Aged Muscle Tonus / drug effects, physiology Muscle, Smooth / drug effects, physiology Propanolamines / pharmacology Pulmonary Ventilation / drug effects, physiology* Receptors, Adrenergic, beta / metabolism* Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Bronchodilator Agents; 0/Carbazoles; 0/Propanolamines; 0/Receptors, Adrenergic, beta; 0K47UL67F2/carvedilol; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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