Document Detail


Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  15864343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonalcoholic fatty liver disease (NAFLD) is a component of the metabolic syndrome, with a clinical spectrum ranging from simple fatty liver to steatohepatitis, cirrhosis, and hepatocellular carcinoma. The primary event of NAFLD is the accumulation of triacylglycerols (TAGs) in hepatocytes. In this issue of the JCI, Donnelly et al. report on their use of stable isotope methodology to show that fatty acids stored in adipose tissue and fatty acids newly made within the liver through de novo lipogenesis are the major sources of TAGs in the liver and are secreted as lipoproteins in NAFLD.
Authors:
Shinji Tamura; Iichiro Shimomura
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  115     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-07-12     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-42     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan. tamuras@imed2.med.osaka-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Animals
Fatty Acids, Nonesterified / blood
Fatty Liver / metabolism*
Hepatocytes / metabolism
Humans
Lipids / biosynthesis*
Mice
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lipids; 0/Triglycerides
Comments/Corrections
Comment On:
J Clin Invest. 2005 May;115(5):1343-51   [PMID:  15864352 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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