Document Detail

Contribution of the addition of anti-β2-glycoprotein to the classification of antiphospholipid syndrome in predicting adverse pregnancy outcome.
MedLine Citation:
PMID:  20874430     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Anti-β2 glycoprotein 1 (a-β2GP1) was added to the criteria for antiphospholipid syndrome (APS) in 2005. However, its clinical significance with respect to complications of pregnancy is not well established. The aim of this study was to evaluate the association of laboratory findings of a-β2GP1 with events of thromboembolism or obstetric complications (pregnancy loss, placental dysfunction, intrauterine growth restriction, preeclampsia, fetal death, and preterm delivery) in women with clinical and laboratory evidence of APS.
METHODS: A retrospective cohort design was used. Ninety-one patients (total 394 pregnancies) referred to a tertiary medical center for evaluation of clinical features consistent with APS were divided into three groups: group A (n = 34), two positive tests for anticardiolipin (ACL) or lupus anticoagulant (LAC), in accordance with original APS classification (1998); group B (n = 18), two positive tests for a-β2GP1, in accordance with the revised APS criteria; and group C (n = 39), only one positive test for ACL or LAC.
RESULTS: Of the 52 women with APS (group A or B), 36 had primary disease, and 16 had secondary disease. On comparison of the groups, group B was characterized by a significantly higher rate of complicated pregnancy (83.3%) than groups A (47.1%) and C (76.9%), P = 0.007, and a higher rate of fetal loss (72.2%) than groups A + C (28.8%, P = 0.001).
CONCLUSIONS: The findings suggest that the revised APS criteria are preferable to the original classification for the prediction of complicated pregnancy.
Galia Oron; Avi Ben-Haroush; Rachel Goldfarb; Yair Molad; Moshe Hod; Jacob Bar
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-09-28
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  24     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-06-21     Revised Date:  2012-09-12    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  606-9     Citation Subset:  IM    
Perinatal Division, The Helen Schneider Hospital for Women, Petach Tikva, Israel.
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MeSH Terms
Abruptio Placentae / diagnosis,  epidemiology
Antiphospholipid Syndrome / classification*,  diagnosis,  immunology
Autoantibodies / analysis*
Cohort Studies
Fetal Death / diagnosis,  epidemiology
Pre-Eclampsia / diagnosis,  epidemiology
Pregnancy Complications / classification,  diagnosis*,  epidemiology,  immunology
Pregnancy Outcome* / epidemiology
Retrospective Studies
beta 2-Glycoprotein I / immunology*
Reg. No./Substance:
0/Autoantibodies; 0/beta 2-Glycoprotein I
Comment In:
J Matern Fetal Neonatal Med. 2012 Aug;25(8):1521   [PMID:  22117118 ]

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