Document Detail

Contribution of Toll-like receptor signaling to germinal center antibody responses.
MedLine Citation:
PMID:  22500832     Owner:  NLM     Status:  MEDLINE    
Toll-like receptors (TLRs) have emerged as one of the most important families of innate immune receptors for initiating inflammation and also for promoting adaptive immune responses. Recent studies have examined the ability of TLRs to promote antibody responses, including T-cell-dependent antibody responses. Initial study suggested that TLR stimulation promotes primarily an extrafollicular antibody response, which rapidly produces moderate affinity antibodies made by short-lived plasma cells. Recent studies, however, have shown that TLRs can also enhance the germinal center response, which produces high affinity class-switched antibody made by long-lived plasma cells. TLR stimulation can increase the magnitude of the latter response and also enhance selection for high affinity IgG. This review summarizes recent advances in understanding the roles of TLRs in B cells and also in other cell types for enhancement of antibody responses, with an emphasis on T-cell-dependent and germinal center antibody responses.
Anthony L DeFranco; Derek C Rookhuizen; Baidong Hou
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  247     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-10     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  64-72     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Antibody Formation / immunology*
B-Lymphocytes / cytology,  immunology,  physiology
Dendritic Cells / immunology
Germinal Center / immunology*
Immunity, Innate
Immunoglobulin G / immunology
Signal Transduction*
Toll-Like Receptors / physiology*
Grant Support
P01 AI078869/AI/NIAID NIH HHS; P01 AI078869-04/AI/NIAID NIH HHS; R01 AI072058/AI/NIAID NIH HHS; R01 AI072058-05/AI/NIAID NIH HHS
Reg. No./Substance:
0/Immunoglobulin G; 0/Toll-Like Receptors

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