Document Detail

Contribution of FliC to epithelial cell invasion by enterohemorrhagic Escherichia coli O113:H21.
MedLine Citation:
PMID:  16982828     Owner:  NLM     Status:  MEDLINE    
Enterohemorrhagic Escherichia coli (EHEC) O113:H21 can invade epithelial cells. In this study, we found that invasion but not adherence was inhibited by anti-FliC(H21) specific antibodies. In addition, deletion of fliC(H21) from EHEC O113:H21 resulted in an eightfold decrease in invasion that was restored upon transcomplementation with fliC(H21) but not with fliC(H6). These results suggested that FliC plays an important role in the pathogenesis of infections caused by EHEC O113:H21 by allowing bacteria to penetrate the intestinal epithelium.
Shelley N Luck; Luminita Badea; Vicki Bennett-Wood; Roy Robins-Browne; Elizabeth L Hartland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-18
Journal Detail:
Title:  Infection and immunity     Volume:  74     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-01-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6999-7004     Citation Subset:  IM    
Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.
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MeSH Terms
Amino Acid Sequence
Cells, Cultured
Epithelial Cells / microbiology*
Escherichia coli / genetics,  pathogenicity*
Escherichia coli Proteins / genetics,  physiology*
Molecular Sequence Data
Sequence Deletion
Reg. No./Substance:
0/Escherichia coli Proteins; 0/FliC protein, E coli

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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