| Contribution of FliC to epithelial cell invasion by enterohemorrhagic Escherichia coli O113:H21. | |
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MedLine Citation:
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PMID: 16982828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enterohemorrhagic Escherichia coli (EHEC) O113:H21 can invade epithelial cells. In this study, we found that invasion but not adherence was inhibited by anti-FliC(H21) specific antibodies. In addition, deletion of fliC(H21) from EHEC O113:H21 resulted in an eightfold decrease in invasion that was restored upon transcomplementation with fliC(H21) but not with fliC(H6). These results suggested that FliC plays an important role in the pathogenesis of infections caused by EHEC O113:H21 by allowing bacteria to penetrate the intestinal epithelium. |
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Authors:
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Shelley N Luck; Luminita Badea; Vicki Bennett-Wood; Roy Robins-Browne; Elizabeth L Hartland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-18 |
Journal Detail:
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Title: Infection and immunity Volume: 74 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-22 Completed Date: 2007-01-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: United States |
Other Details:
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Languages: eng Pagination: 6999-7004 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Cells, Cultured Epithelial Cells / microbiology* Escherichia coli / genetics, pathogenicity* Escherichia coli Proteins / genetics, physiology* Humans Molecular Sequence Data Sequence Deletion |
| Chemical | |
Reg. No./Substance:
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0/Escherichia coli Proteins; 0/FliC protein, E coli |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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