| The contribution of early nephropathy to cardiovascular risk. | |
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MedLine Citation:
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PMID: 20621247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with an estimated glomerular filtration rate (eGFR) of less than 60 mL/min per 1.72 m(2), and presence of microalbuminuria (MA), have an increased risk of cardiovascular (CV) events, compared with patients with normal renal function. The strength of the association among patients with a mild reduction in eGFR depends largely on the population studied, whereas the data regarding MA show an elevated risk among both low- and high-risk populations. Patients with mildly reduced eGFR or MA experience a reduction in CV events and progression of renal disease with treatment of CV risk factors. For patients who experience a myocardial infarction, observational data suggest that patients with a mildly reduced eGFR also have improved outcomes with an early invasive strategy, compared with a noninvasive strategy. However, whether targeting therapy to normalize renal function also confers a reduction in CV events remains unknown. |
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Authors:
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Tamar S Polonsky; Francesco Locatelli |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiology clinics Volume: 28 ISSN: 1558-2264 ISO Abbreviation: Cardiol Clin Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8300331 Medline TA: Cardiol Clin Country: Netherlands |
Other Details:
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Languages: eng Pagination: 427-36 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Albuminuria / complications*, epidemiology, therapy Cardiovascular Diseases / complications*, drug therapy, epidemiology* Confounding Factors (Epidemiology) Europe / epidemiology Female Glomerular Filtration Rate Humans Kidney Diseases / complications*, diagnosis, epidemiology, urine Male Middle Aged Prevalence United States / epidemiology Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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