| Contribution of Cerebrospinal Fluid Thymosin β4 Levels to the Clinical Differentiation of Creutzfeldt-Jakob Disease. | |
| | |
MedLine Citation:
|
PMID: 22431836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To asses thymosin β4 specificity as relevant to the diagnosis of Creutzfeldt-Jakob disease (CJD). DESIGN: A matrix-assisted laser desorption ionization time-of-flight mass spectrometry protein profiling analysis was applied to several neurological disorders that are known to lead to dementia. The relative peak area (percentage of area) of the thymosin β4 MS signal was taken into account. SETTING: National Research Council, Cosenza, Italy. Patients Cerebrospinal fluid analysis was performed on 21 patients with neuropathologically confirmed CJD; 15 patients with frontotemporal dementia; 18 patients with probable Alzheimer disease; and 9 patients with a rapid-onset progressive dementia. A non-cognitively impaired control group consisted of 25 individuals without CJD or dementia. MAIN OUTCOME MEASURES: The thymosin β4 test results in CJD and other dementia. RESULTS: The thymosin β4 cerebrospinal fluid levels appeared to be markedly increased in CJD samples compared with frontotemporal cases (P = 10(-7)) and patients with Alzheimer disease (P = 10(-7)). A lower significance was observed vs the group with rapid-onset progressive dementia (P = .0004). Thus, at a cutoff value of 1.2% of the thymosin β4 relative peak area, we estimated 100% sensitivity with 98.5% specificity. CONCLUSION: These findings indicate that cerebrospinal fluid levels of thymosin β4 protein measured by matrix-assisted laser desorption ionization time-of-flight mass spectrometry may effectively contribute to discriminate CJD from other forms of dementia. |
| | |
Authors:
|
Maria Le Pera; Elena Urso; Teresa Sprovieri; Sabrina Bossio; Umberto Aguglia; Ida Manna; Chiara Cupidi; Tiziana Ferraro; Antonio Gambardella; Antonio Qualtieri; Aldo Quattrone |
Related Documents
:
|
21637346 - Role of il-1 beta in the development of human t(h)17 cells: lesson from nlpr3 mutated p... 22266456 - Association of plasma cystatin c levels with angiographically documented coronary arter... 21700606 - Unrecognized ventricular dysfunction in chronic obstructive pulmonary disease. 22209156 - The inflammatory biomarker ykl-40 as a new prognostic marker for all-cause mortality in... 22523726 - The therapeutic and diagnostic value of 2-week high dose proton pump inhibitor treatmen... 6896806 - The early diagnosis of atypical thyroid acropachy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-19 |
Journal Detail:
|
Title: Archives of neurology Volume: - ISSN: 1538-3687 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
National Research Council, Piano Lago di Mangone (Cs) (Drs Le Pera, Urso, Sprovieri, Manna, Ferraro, Gambardella, and Qualtieri), Hematology Unit, Azienda Ospedaliera, Cosenza (Dr Bossio), Institute of Neurology, University Magna Graecia of Catanzaro, Catanzaro (Drs Aguglia and Quattrone), and Department of Clinical Neurosciences, University of Palermo, Palermo (Dr Cupidi), Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Age and Rate of Cognitive Decline in Alzheimer Disease: Implications for Clinical Trials.
Next Document: Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker M...