Document Detail

Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8(+) memory T cells in the bone marrow.
MedLine Citation:
PMID:  22886791     Owner:  NLM     Status:  Publisher    
The persistence of memory lymphocytes is a critical feature of adaptive immunity. The TNF family ligand 4-1BBL supports the antigen-independent survival of CD8(+) memory T cells. Here we show that mice lacking 4-1BB only on αβ T cells show a similar defect in CD8(+) T-cell recall responses, as previously shown in 4-1BBL deficient mice. We show that 4-1BB is selectively expressed on bone marrow CD8(+) but not CD4(+) memory T cells of unimmunized mice. Its ligand, 4-1BBL, is found on VCAM-1(+) stromal cells, CD11c(+) cells and a Gr1(lo) myeloid population in unimmunized mice. Adoptive transfer of in vitro-generated memory T cells into mice lacking 4-1BBL only on radioresistant cells recapitulates the defect in CD8(+) T-cell survival seen in the complete knockout mice, with smaller effects of 4-1BBL on hematopoietic cells. In bone marrow, adoptively transferred DsRed CD8(+) memory T cells are most often found in proximity to VCAM-1(+) cells or Gr1(+) cells, followed by B220(+) cells and to a much lesser extent near CD11c(+) cells. Thus a VCAM-1(+) CD45(-) stromal cell is a plausible candidate for the radioresistant cell that provides 4-1BBL to CD8(+) memory T cells in the bone marrow.
Gloria H Y Lin; Fanny Edele; Achire N Mbanwi; Michael E Wortzman; Laura M Snell; Mariana Vidric; Katrin Roth; Anja E Hauser; Tania H Watts
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-7
Journal Detail:
Title:  European journal of immunology     Volume:  -     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
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