| Contrasting renal effects of nicotine in smokers and non-smokers. | |
| | |
MedLine Citation:
|
PMID: 9568854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cigarette smoking is associated with acute increase in arterial pressure due to systemic vasoconstriction and decreased skin and coronary blood flow. Virtually all cardiovascular effects of cigarette smoking are due to nicotine. However, whether nicotine also affects the renal circulation and function in humans is at present unknown. METHODS: In the current study the acute effects of a 4-mg nicotine gum on arterial pressure, heart rate as well as renal haemodynamics and function were assessed in non-smokers and chronic smokers. RESULTS: In non-smokers, mean arterial pressure (+8 +/- 1 mmHg, P<0.001) and heart rate (+13 +/- 3 beats/min, P<0.001) increased whereas effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) decreased by 15 +/- 4% and 14 +/- 4% respectively; in addition, urinary cyclic GMP decreased by 51 +/- 12% in response to nicotine administration. In smokers, mean arterial pressure and heart rate increased similarly; however, in contrast with non-smokers, ERPF and GFR remained unchanged whereas urinary cyclic GMP rose by 87 +/- 43%. Changes in ERPF induced by nicotine were positively correlated with changes in urinary cyclic GMP. CONCLUSIONS: These findings indicate that nicotine administration is associated with renal vasoconstriction in healthy non-smokers, possibly through alteration of a cyclic-GMP-dependent vasoactive mechanism. Tolerance to the renal effect of nicotine was observed in chronic smokers, despite the maintenance of the systemic response to nicotine. |
| | |
Authors:
|
J M Halimi; C Philippon; A Mimran |
Related Documents
:
|
16434504 - Urinary albumin excretion as a predictor of the development of hypertension in the gene... 15365804 - Pathomechanisms and the diagnosis of arterial hypertension in pediatric renal allograft... 760254 - Dynamics of upper urinary tract during pacemaker blockade induced by pentobarbital. 9449384 - Inducible nitric oxide synthase and blood pressure. 11177924 - Ultrafast formation of nonemissive species via intermolecular interaction in single cry... 9928854 - The role of coronary perfusion changes in cardiac dysfunction associated with brain death. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 13 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 1998 Apr |
Date Detail:
|
Created Date: 1998-06-11 Completed Date: 1998-06-11 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 940-4 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Centre Hospitalier Universitaire, Montpellier, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cyclic GMP / urine Female Hemodynamics / drug effects Humans Kidney / drug effects* Male Nicotine / toxicity* Renin / blood Smoking / physiopathology* |
| Chemical | |
Reg. No./Substance:
|
54-11-5/Nicotine; 7665-99-8/Cyclic GMP; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-glomerular basement membrane (GBM)-antibody-mediated disease with normal renal function.
Next Document: High prevalence of carotid artery disease in patients with atheromatous renal artery stenosis.