| Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. | |
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MedLine Citation:
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PMID: 15480365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine prevalence of metabolic syndrome (MS) among adolescents by using definitions from the National Cholesterol Education Program Adult Treatment Panel III (NCEP) and World Health Organization (WHO) guidelines and to compare the populations identified by these definitions. STUDY DESIGN: School-based, cross-sectional study of 1513 black, white, and Hispanic teens who had a fasting morning blood sample drawn and a physical examination. RESULTS: Overall, the prevalence of NCEP-defined MS was 4.2% and of WHO-defined MS was 8.4%. MS was found almost exclusively among obese teens, for whom prevalence of NCEP-defined MS was 19.5% and prevalence of WHO-defined MS was 38.9%. Agreement between definitions was poor (kappa statistic=0.41). No race or sex differences were present for NCEP-defined MS. However, nonwhite teens were more likely to have MS by WHO criteria (RR, 1.40; 95% CI, 1.04, 1.87), and MS was more common among girls if the WHO-based definition was used (RR, 1.26; 95% CI, 1.08, 1.88). CONCLUSIONS: Among adolescents, obesity is a powerful risk for MS. Important demographic and clinical differences exist in the typology of MS, depending on the definition. Such discrepancies suggest that the concept of a common pathologic syndrome or etiologic mechanism underlying MS as defined by these guidelines may be flawed. |
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Authors:
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Elizabeth Goodman; Stephen R Daniels; John A Morrison; Bin Huang; Lawrence M Dolan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 145 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-13 Completed Date: 2004-12-07 Revised Date: 2010-08-11 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 445-51 Citation Subset: AIM; IM |
Affiliation:
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Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts 02454, USA. goodman@brandeis.edu <goodman@brandeis.edu> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Continental Ancestry Group* Child Cohort Studies European Continental Ancestry Group* Female Hispanic Americans* Humans Male Metabolic Syndrome X / diagnosis*, ethnology* Practice Guidelines as Topic Prevalence Risk Factors World Health Organization |
| Grant Support | |
ID/Acronym/Agency:
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DK59183/DK/NIDDK NIH HHS; HD41527/HD/NICHD NIH HHS; M01-RR-08084/RR/NCRR NIH HHS; R01 HD041527-03/HD/NICHD NIH HHS |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2004 Oct;145(4):427-30
[PMID:
15480357
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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