Document Detail

Contrasting presentation and findings between patients with rheumatic complaints taking nonsteroidal anti-inflammatory drugs and a general population referred for endoscopy.
MedLine Citation:
PMID:  3484649     Owner:  NLM     Status:  MEDLINE    
One hundred and fifty patients with various rheumatic complaints who were taking nonsteroidal anti-inflammatory drugs (NSAIDs) and required upper gastrointestinal endoscopy were compared with 150 patients, matched for age and sex, who were also referred for gastroscopy but who did not have rheumatic complaints and were not taking these drugs. A comparison was made between the indications for endoscopy and the endoscopic findings in the two groups. Significant differences were found. Fewer patients with rheumatic complaints had normal findings, more had chronic gastric ulcer, duodenal ulcer, gastritis or mucosal erosions. Patients with rheumatic complaints were referred more frequently for anaemia and less frequently for dysphagia or abdominal symptoms. The increased severity of gastric morbidity in patients with rheumatism is probably due to damage caused by NSAIDs. The frequency and severity of upper gastrointestinal lesions in patients with rheumatic complaints taking NSAIDs cannot be estimated from the patient's complaint rate, anaemia rather than pain being the most frequent finding. Upper gastrointestinal tract endoscopy is required to make a definitive diagnosis. This has important implications for the licensing policies of regulatory authorities when considering the licensing of new nonsteroidal anti-inflammatory drugs.
A J Collins; J Davies; S A Dixon
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of rheumatology     Volume:  25     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-24     Completed Date:  1986-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia / complications
Anti-Inflammatory Agents / therapeutic use*
Dyspepsia / etiology
Gastrointestinal Diseases / complications*,  diagnosis,  physiopathology
Gastrointestinal Hemorrhage / complications
Middle Aged
Referral and Consultation
Rheumatic Diseases / complications*,  drug therapy,  physiopathology
Reg. No./Substance:
0/Anti-Inflammatory Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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