| Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. | |
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MedLine Citation:
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PMID: 11677047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin. |
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Authors:
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J P Spencer; H Schroeter; A J Crossthwaithe; G Kuhnle; R J Williams; C Rice-Evans |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical biology & medicine Volume: 31 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-25 Completed Date: 2002-01-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 1139-46 Citation Subset: IM |
Affiliation:
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Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caspase 3 Caspases / drug effects, metabolism Catechin / analogs & derivatives, metabolism, pharmacology* Cell Death / drug effects Cell Survival / drug effects, physiology Cells, Cultured Cerebral Cortex / cytology Dermis / cytology Fibroblasts / drug effects*, metabolism Flavonoids / pharmacology Glucuronides / metabolism Humans Hydrogen Peroxide / antagonists & inhibitors*, pharmacology* Methylation Mice Neurons / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Glucuronides; 154-23-4/Catechin; 7722-84-1/Hydrogen Peroxide; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Casp3 protein, mouse; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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