Document Detail

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts.
MedLine Citation:
PMID:  11677047     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.
J P Spencer; H Schroeter; A J Crossthwaithe; G Kuhnle; R J Williams; C Rice-Evans
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  31     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-25     Completed Date:  2002-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-46     Citation Subset:  IM    
Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College, London, UK.
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MeSH Terms
Caspase 3
Caspases / drug effects,  metabolism
Catechin / analogs & derivatives,  metabolism,  pharmacology*
Cell Death / drug effects
Cell Survival / drug effects,  physiology
Cells, Cultured
Cerebral Cortex / cytology
Dermis / cytology
Fibroblasts / drug effects*,  metabolism
Flavonoids / pharmacology
Glucuronides / metabolism
Hydrogen Peroxide / antagonists & inhibitors*,  pharmacology*
Neurons / drug effects*,  metabolism
Reg. No./Substance:
0/Flavonoids; 0/Glucuronides; 154-23-4/Catechin; 7722-84-1/Hydrogen Peroxide; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Casp3 protein, mouse; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases

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