Document Detail

Contrasting effects of vasodilators on oxygen tension and membrane potential of canine gastric surface epithelium.
MedLine Citation:
PMID:  7245049     Owner:  NLM     Status:  MEDLINE    
Our purpose was to study the effects of three related vasoactive drugs on gastric epithelial oxygenation and metabolism. By means of an ultramicroelectrode technique, oxygen tension and transmembrane potential difference of surface epithelium were determined in an in vivo canine gastric chamber model. Intra-arterial papaverine (30 micrograms kg-1 min-1) caused a significant depression of epithelial PO2 and potential difference (PD), a transient inhibition of total gastric oxygen consumption, and a 70% increase in total gastric blood flow. Following cessation of the papaverine infusion, epithelial PO2 and PD continued to decline, whereas gastric blood flow and oxygen consumption return to baseline. Isoproterenol (0.0125 microgram kg-1 min-1), on the other hand, had no significant effect on epithelial PO2 and PD although it increased total gastric blood flow 33%. Dopamine (0.1 microgram kg-1 min-1) had no significant hemodynamic effects. To test the importance of papaverine-induced epithelial hypoxia, hydrochloric acid (160 mM) and sodium taurocholate (3 mM) were added to the epithelial bathing solution during intra-arterial infusion of either papaverine or isoproterenol. Necrosis and ulceration of the gastric mucosa were seen with the infusion of papaverine but not with the infusion of isoproterenol. Our results indicate that papaverine increases total gastric blood flow at the expense of nutrient blood flow to surface epithelium. We conclude that nutrient blood flow to surface epithelium is critical to the ability of the gastric mucosa to resist injury by luminal acid and bile. Furthermore, papaverine should not be used clinically to enhanced gastric blood flow because it is potentially injurious to the mucosa.
J C Bowen; J C LeDoux; J L Ochsner; M G Ochsner; J G Payne
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  90     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  AIM; IM    
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MeSH Terms
Dopamine / pharmacology
Epithelium / metabolism
Gastric Mucosa / blood supply,  metabolism,  physiology*
Isoproterenol / pharmacology
Membrane Potentials / drug effects
Oxygen / blood
Oxygen Consumption*
Papaverine / pharmacology
Regional Blood Flow / drug effects
Vasodilator Agents / pharmacology*
Grant Support
Reg. No./Substance:
0/Vasodilator Agents; 58-74-2/Papaverine; 7683-59-2/Isoproterenol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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